Thesis
Cancer-related
Deuterium Depletion Improves Survival in Pancreatic Cancer by Inhibiting Cell Proliferation, RNA, and Nuclear Membrane Turnover
These results strongly suggest that DDW treatment provides additional benefits to pancreatic cancer patients and plays a crucial role in delaying disease progression.
2021, Department of Pediatrics, Harbor-UCLA Medical Center & Lundquist Institute for Biomedical Innovation, Torrance, California, USA
Deuterium Depletion May Delay the Progression of Prostate Cancer
Based on preclinical toxicology studies, prospective, and retrospective clinical studies, DDW application at concentrations of 25 to 105 ppm D is completely safe and can serve as a highly effective tool in cancer therapy. As a result, DDW application in high-risk populations may reduce prostate cancer mortality, delay progression in histologically confirmed cases, and extend median survival time (MST).
2011, St. John Hospital, Budapest, Hungary
Effects of Deuterium-Depleted Water on Survival of Lung Cancer Patients and Expression of Kras, Bcl2, and Myc Genes in Mouse Lungs
Since DDW extends survival in lung cancer patients, it is a promising non-toxic agent for lung cancer treatment. The observed survival benefits in women and the sex-specific regulation of primary tumor gene expression by DDW warrant further investigation.
2011, Department of Public Health, University of Pécs Medical School, Pécs, Hungary
Preclinical and Clinical Data Confirm the Anticancer Effects of Deuterium Depletion
Mitochondria that produce DDW, which determines the ²H/¹H ratio, along with activated H⁺ transport systems, are proposed as key mechanisms in cancer prevention and therapy. These mechanisms include natural ketogenic diets, deuterium-depleted drinking water, and the mitochondrial downstream effects of targeted cancer drugs such as Avastin and Glivec. The biological role of ²H may be a missing link in solving complex cancer puzzles.
2016, HYD LLC Cancer Research & Drug Development Company, Für Street 2, Budapest 1124, Hungary
Submolecular Regulation of Cellular Transformation via Deuterium Depletion-Driven Hydrogen Exchange in the Tricarboxylic Acid Substrate Cycle
In conclusion, ²H depletion in water provides a novel adjuvant and protective cancer therapy.
2015, Department of Pediatrics, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance, California, USA
Retrospective Study on the Survival of Breast Cancer Patients Undergoing Deuterium Depletion in Addition to Standard Therapy
Compared to published data, DDW therapy significantly extended MST in specific subgroups of breast cancer patients when combined with or as an extension of standard therapy. Deuterium depletion may be a highly effective strategy for preventing breast cancer recurrence. Additionally, this method is safe and can be easily integrated into standard breast cancer treatment regimens.
2013, HYD LLC Cancer Research & Drug Development Company, Budapest H-1124, Hungary
Biological Significance of Naturally Occurring Deuterium: Antitumor Effects of Deuterium Depletion
Reducing D concentration may interfere with signaling pathways, leading to tumor regression. Deuterium depletion may introduce new perspectives in cancer therapy and prevention, helping to enhance the efficacy of current anticancer treatments.
2010, HYD Rákkutató és Gyógyszerfejlesztő Kft, Budapest, Hungary
. Deuterium Depletion Improves Pancreatic Cancer Survival by Inhibiting Cell Proliferation, RNA, and Nuclear Membrane Turnover
Different concentrations of deuterium-depleted water (DDW) slowed the growth of MIA-PaCa-2 pancreatic cancer cells. Clinical trials in advanced pancreatic cancer patients showed that those receiving DDW had significantly improved median survival times compared to those receiving chemotherapy alone (19.6 months vs. 6.36 months). This study found a strong correlation between survival extension and DDW treatment frequency and duration.
2021, Department of Pediatrics, Harbor-UCLA Medical Center & Lundquist Institute for Biomedical Innovation, Torrance, California, USA
Retrospective Evaluation of the Effects of Deuterium-Depleted Water Consumption in Four Patients with Brain Metastases from Lung Cancer
Combining deuterium-depleted water with standard treatments significantly prolonged survival in four lung cancer patients with brain metastases and demonstrated varying degrees of tumor response. This highlights the potential of DDW as an effective adjunct cancer therapy.
2008, HYD LLC Cancer Research & Drug Development Company, Budapest, Hungary
Deuterium-Depleted Water in Cancer Therapy: A Systematic Review of Clinical and Experimental Studies
Deuterium-depleted water, whether used alone or in combination with chemotherapy, significantly inhibits cancer progression, with combination therapy being more effective. DDW functions by regulating ROS-related genes in the Keap1-Nrf2 pathway, controlling ROS production.
2024, Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang 330031, China
Deuterium Depletion Induces Cell Cycle Arrest and Inhibits the Proliferation of Human MCF7 Breast Cancer Cells
Deuterium-depleted water at concentrations of 30-100 ppm caused G1/S phase arrest and increased antioxidant enzyme activity, significantly suppressing MCF7 breast cancer cell growth. It also enhanced the inhibitory effects of 5-FU, suggesting potential synergy. DDW may serve as a strategic addition to breast cancer treatment and a promising adjunct to conventional chemotherapy in future trials.
2019, Nuclear Science and Technology Research Institute, Tehran, Iran
Effects of Deuterium-Depleted Water on Lung Cancer Patient Survival and Expression of Kras, Bcl2, and Myc Genes in Mouse Lungs
A clinical study of 129 lung cancer patients found that deuterium-depleted water (DDW) significantly extended survival, especially in women (74.1 months in females vs. 25.9 months in males). DDW also reduced the expression of cancer-related genes Bcl2, Kras, and Myc in mouse lungs, suggesting its potential as a non-toxic anticancer supplement.
2013, Department of Public Health, University of Pécs Medical School, Pécs, Hungary
Advances in Research on the Antitumor Effects of Deuterium-Depleted Water
Low concentrations of deuterium water (<65 ppm) inhibit cancer growth. Clinical trials suggest that consuming 10-20 ppm DDW halts malignant cell growth, extends survival, and improves cancer patients' quality of life. DDW differs from many conventional anticancer drugs by lacking severe side effects and being easy to administer.
2012, Sino-American Cancer Research Institute, Guangdong Medical University, Dongguan, China
In Vitro Evaluation of the Antitumor Effects of Deuterium-Depleted Water
DDW alone had minimal impact on cell line growth but significantly enhanced the inhibitory effects of paclitaxel, particularly in breast and prostate cancer cell lines.
2014, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Deuterium-Depleted Environment Suppresses the Growth of Gastric Cancer Cells: An In Vitro Study
At 25 ppm deuterium, SGC-7901 gastric cancer cells exhibited a 10% reduction in proliferation, suppressed wound healing and colony formation, increased G1 phase cell percentage, and decreased S phase cell percentage compared to a 150 ppm environment. Downregulation of PCNA and G1 phase cell cycle arrest contributed to these effects. No significant differences in apoptosis were observed between the two groups.
2017, Department of Geriatric Gastroenterology, General Hospital of the People’s Liberation Army, China
Synergistic Anticancer Effects of Deuterium-Depleted Water and Crocin on HT-29 Colon Cancer Cells
This study examined the synergistic effects of deuterium-depleted water (DDW) and crocin on HT-29 colon cancer cells. The combination more effectively inhibited cell growth than DDW alone, increased the proportion of cells in G0 and G1 phases, decreased cells in S, G2, and M phases, and reduced antioxidant enzyme activity while increasing malondialdehyde levels. These results suggest that DDW and crocin could be a novel strategy for colon cancer prevention and treatment.
2023, Faculty of Food Science and Technology, Islamic Azad University, Science and Research Branch, Iran
Deuterium-Depleted Water Inhibits Human Lung Cancer Cell Growth by Inducing Apoptosis
DDW significantly inhibited A549 lung cancer cell growth, leading to apoptotic changes and alterations in cell cycle progression. In mouse models, DDW reduced tumor weight by approximately 30%, supporting its potential as a clinically applicable anticancer agent.
2010, School of Life Science and Biotechnology, Shanghai Jiao Tong University, China
Anti-inflammatory and Anti-tumor Effects of Hydrogen via Reactive Oxygen Species (Review)
H₂ may reduce the risk of lifestyle-related diseases and cancer, and it can be used to treat various diseases by protecting nuclear DNA and mitochondria.
2018, Shanghai Jiao Tong University School of Medicine, Shanghai General Hospital, Department of Obstetrics and Gynecology, China
Antitumor Activity of Protons and Molecular Hydrogen: Underlying Mechanisms
The greatest advantage of H₂ is its ability to penetrate biological membranes and its mild side effects. Under these conditions, H₂ and its various donor forms may represent a new therapeutic strategy for cancer treatment.
2021, University of Burgundy-Franche-Comté, Faculty of Health Sciences, PEC2 (EA7460), Dijon, France
Hydrogen Protects BALB/c Mice from Radiation-induced Thymic Lymphoma
Ionizing radiation (IR) is a well-known carcinogen, but the mechanisms of radiation-induced thymic lymphoma remain unclear. Additionally, no simple or effective method for protecting mice from radiation-induced thymic lymphoma has been identified. In this study, we found that H₂ protects BALB/c mice from radiation-induced thymic lymphoma.
2011, Second Military Medical University, Department of Radiation Medicine, Xiangyin Road, Shanghai 200433, China
Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Based on Gene Expression
H₂ has demonstrated excellent antitumor efficacy in cell models, animal models, and human clinical trials. The mechanisms of its efficacy may involve both direct removal of hydroxyl radicals (·OH) and indirect biological defense mechanisms through gene expression regulation. H₂ has shown great efficacy and safety as an antitumor agent, offering a new therapeutic strategy for cancer treatment.
2021, MiZ Company, Research & Development Department, Ōfuna 2-19-15, Kamakura, Kanagawa 247-0056, Japan
Therapeutic Potential of Molecular Hydrogen in Ovarian Cancer
In vitro studies show that hydrogen treatment significantly inhibits proliferation, invasion, migration, and colony formation in both Hs38.T and PA-1 cancer cells. A key finding of this study was that molecular hydrogen distinctly suppressed sphere-forming ability in both PA-1 and Hs38.T cells.
2018, Beijing Institute of Technology, Beijing Molecular Hydrogen Research Center, Department of Life Sciences and Biotechnology, Beijing 100124, China
Real Investigation of Hydrogen-Controlled Cancer: A Follow-up Report on 82 Advanced Cancer Patients
Hydrogen inhalation is a simple and inexpensive therapy with minimal side effects, making it a promising approach for clinical rehabilitation in advanced cancer patients.
2023, Jinan University, Fuda Cancer Hospital, Department of Cancer Rehabilitation, Guangzhou, Guangdong, China
Protective Effects of Hydrogen Gas Inhalation Against Radiation-induced Bone Marrow Damage: A Retrospective Observational Study in Patients
Results showed that H₂ gas inhalation therapy reduced bone marrow damage caused by IMRT while not diminishing anticancer effects, suggesting that H₂ gas inhalation could be an effective treatment for IMRT-induced bone marrow damage.
2021, Clinic C4, Tokyo, Japan
Two Weeks of Hydrogen Inhalation Reverses Aging of Adaptive and Innate Immune Systems in Patients with Advanced Non-Small Cell Lung Cancer: A Self-Controlled Study
After two weeks of hydrogen therapy, levels of exhausted and senescent cytotoxic T cells returned to normal, while killer Vδ1 cells increased. Functional helper T cells, cytotoxic T cells, Th1 cells, total natural killer cells, and Vδ2 cells also normalized. This suggests that hydrogen therapy significantly improves immune function in advanced non-small cell lung cancer.
2019, Jinan University, Fuda Cancer Hospital, Guangzhou, Guangdong, China
Hydrogen Therapy Inhibits Tumor Progression and Reduces Drug Side Effects in Patients with Advanced Non-Small Cell Lung Cancer
After 16 months, the progression-free survival rate of the control group was lower than that of the H₂ monotherapy group and significantly lower than that of the H₂ combination therapy group. Drug-related side effects decreased or disappeared in the combination therapy group. H₂ inhalation helps inhibit tumor progression and reduce side effects in patients with advanced non-small cell lung cancer.
2019, Jinan University, Fuda Cancer Hospital, Guangzhou, Guangdong, China
Systematic Review of Molecular Hydrogen Therapy in Cancer Management
Out of 677 papers, 27 met the criteria and were summarized. Despite variations in H₂ administration methods, study designs, and cancer types, the results were consistently positive. H₂ therapy shows promise in improving survival, quality of life, blood biomarkers, and tumor reduction, both as a standalone and adjuvant therapy.
2023, International Medical University, Faculty of Medicine and Health Sciences, Kuala Lumpur 57000, Malaysia
Hydrogen Gas in Cancer Treatment
Gas signaling molecules such as oxygen, carbon monoxide, nitric oxide, and hydrogen sulfide regulate signal transduction and cellular homeostasis, showing potential for cancer treatment. Recent evidence suggests that H₂ has anti-inflammatory, anti-ROS, and antitumor properties. Studies indicate that H₂ can reduce chemotherapy side effects and inhibit tumor growth. This review summarizes research on H₂’s therapeutic potential and underlying mechanisms.
2019, Southern Medical University, Department of Pharmacy, Integrated Traditional Chinese Medicine Hospital, Guangzhou, China
Complete Disappearance of Brain Metastases in Non-Small Cell Lung Cancer Following Hydrogen Gas Inhalation: A Case Report
A 44-year-old woman with metastatic lung cancer initially responded to targeted therapy, but after 28 months, new metastases and hydrocephalus developed. In April 2018, hydrogen gas monotherapy was initiated. After four months, brain tumors and hydrocephalus significantly regressed. After one year, brain tumors disappeared, and liver and lung metastases stabilized. This suggests that hydrogen gas monotherapy can control tumors and extend survival when standard treatments fail.
2019, Jinan University, Fuda Cancer Hospital, Guangzhou 510665, China
Hydrogen Gas: From Anti-inflammatory Therapy to Cancer Treatment
Hydrogen (H₂) therapy is promising due to its safety, but current systemic administration lacks targeting and efficiency. The anticancer mechanisms of H₂ remain unclear. Nanomaterials ideal for drug delivery may enhance targeted H₂ delivery and production, improving therapeutic efficacy.
2019, Fuzhou University, College of Chemistry, Ministry of Education Key Laboratory of Food Safety and Bioanalysis, National Key Laboratory of Photocatalysis for Energy and Environment, Fuzhou, China
Hydrogen Gas Suppresses Lung Cancer Progression via Downregulation of CD47
H₂ treatment reduced CD47 and CDC42 expression in a dose-dependent manner. Increasing CD47 reversed H₂'s apoptosis-promoting, growth-inhibiting, and migration-inhibiting effects, while CD47 inhibition enhanced these effects. H₂ also reduced CD47 and CDC42 in mouse tumors and increased macrophage-mediated phagocytosis. These findings suggest that H₂ suppresses lung cancer progression by downregulating CD47.
2020, Third Hospital of Hebei Medical University, Department of Rheumatology and Immunology, Shijiazhuang, Hebei, China
Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway
Hydrogen therapy inhibited CRC cell proliferation independently of apoptosis, showing dose-dependent responses. In vivo, CRC tumor volume and weight were significantly reduced. H₂ decreased pAKT/SCD1 levels, suppressing CRC cell proliferation, and this process was reversed by the AKT activator SC79. Higher SCD1 expression in CRC tissues correlated with advanced TNM stage, lymph node metastasis, and lack of CRC family history. These findings suggest that high-dose H₂ targets the pAKT/SCD1 pathway to inhibit CRC.
2022, Qingdao University, School of Basic Medicine, Department of Pathophysiology, Qingdao 266000, China
Hydrogen Inhibits Gastric Cancer Cell Proliferation and Migration via the lncRNA MALAT1/miR-124-3p/EZH2 Axis
H₂ gas inhibited gastric tumor growth in vivo and reduced gastric cancer cell proliferation, migration, and lncRNA MALAT1 and EZH2 expression while increasing miR-124-3p expression. Overexpression of lncRNA MALAT1 reversed these effects. lncRNA MALAT1 and miR-124-3p were inversely related. A miR-124-3p mimic suppressed EZH2 expression and cancer cell proliferation and migration induced by lncRNA MALAT1.
2021, Fudan University, Zhongshan Hospital Qingpu Branch, Shanghai, China
Molecular Hydrogen Promotes the Proliferation of Cancer Cells with Strong Mitochondrial Protein Response
Although molecular hydrogen is less studied in cancer, it promoted proliferation in four out of seven human cancer cell lines (responders). This effect was independent of reactive oxygen species levels. Responders exhibited higher mitochondrial ETC gene expression, mass, peroxide levels, membrane potential, and spare respiratory capacity. Hydrogen induced the mitochondrial unfolded protein response (mtUPR) and reversed rotenone-induced inhibition. Thus, hydrogen activates mtUPR, promoting proliferation in cancer cells with high mitochondrial ETC activity.
2022, Nagoya University Graduate School of Medicine, Center for Neurological Disease and Cancer, Department of Neurogenetics, Nagoya 466-8550, Japan
Overview of Ovarian Cancer: Related Molecular Processes and Development of Target-Based Chemotherapy
Ovarian cancer is one of the leading causes of cancer death in Western women. Despite advances in genomics, proteomics, and radiomics, treatment remains challenging. Researchers are focusing on molecular processes to develop new chemotherapies. This review summarizes current progress and future directions. Most patients remain asymptomatic until late-stage disease, with persistent issues of drug resistance and recurrence. This review discusses theoretical approaches and success stories in chemotherapy development, providing insights into future treatment strategies.
2021, National Institute of Technical Teachers Training and Research, Department of Applied Sciences, India
Hydrogen and Oxygen Mixture Improves Cardiac Dysfunction and Pathological Changes in Rats with Intermittent Hypoxia-induced Heart Failure
Obstructive sleep apnea (OSA) causes intermittent blood oxygen fluctuations, generating reactive oxygen species (ROS). In a chronic intermittent hypoxia (CIH) rat model, H₂-O₂ therapy improved cardiac function and reduced myocardial fibrosis. The H₂-O₂ mixture reduced ER stress, apoptosis, and ROS levels, demonstrating hydrogen's potential as an antioxidant against CIH-induced oxidative stress damage.
2019, Hebei University of Chinese Medicine, Scientific Research Center, Shijiazhuang 050200, China
Preventive and Therapeutic Effects of Molecular Hydrogen on Oxidative Stress-related Ophthalmic Diseases and Injuries
Oxidative stress contributes to various diseases, particularly ophthalmic disorders, due to excessive ROS production and reduced natural antioxidants. Molecular hydrogen (H₂) is an effective antioxidant that crosses the blood-brain and blood-retinal barriers, penetrating tissues and scavenging ROS. It also has anti-inflammatory, anti-apoptotic, and cytoprotective effects while being non-toxic even at high doses. Studies show that H₂ therapy reduces oxidative stress, preventing or improving ophthalmic diseases and, in severe cases, slowing disease progression.
2019, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic
Hydrogen Gas Inhalation Alleviates Radiation-induced Bone Marrow Damage in Cancer Patients
IMRT and HCC therapy reduced white blood cells (WBC) and platelets (PLT) but had no impact on red blood cells (RBC), hemoglobin (HGB), or hematocrit (HCT). H₂ gas treatment significantly mitigated WBC and PLT reduction while maintaining anticancer efficacy. Thus, H₂ gas inhalation may be a strategy to reduce IMRT-induced bone marrow damage in cancer patients.
2019, Keio University, Japan
Medical Applications of Hydrogen
Hydrogen (H₂) is gaining attention both as a clean fuel and for its medical benefits. Research indicates that hydrogen's antioxidant properties enable it to neutralize reactive oxygen species (ROS) to treat diseases. Since 2007, when Ohsawa et al. first demonstrated its effect in reducing brain damage, hydrogen has shown efficacy in diabetes, kidney disease, stroke, inflammation, radiation therapy side effects, wrinkles, and fatigue. Hydrogen specifically targets toxic hydroxyl radicals (•OH), easily penetrates cells, and is safe even at tested doses.
2021, Neuroscience Research Institute, Gachon University, Incheon, South Korea
Molecular Hydrogen as a Potentially Clinically Applicable Radioprotectant
Ionizing radiation in medical treatments induces DNA damage and free radical generation. Molecular hydrogen (H₂) may counteract this by scavenging harmful hydroxyl radicals (•OH). Studies confirm hydrogen's safety and efficacy. This review highlights its antioxidant properties, anti-inflammatory effects, apoptosis inhibition, and gene expression regulation, suggesting its potential as a radioprotectant.
2021, MiZ Company, Research & Development Department, Ōfuna 2-19-15, Kamakura, Kanagawa 247-0056, Japan
The "Quantum Leap" of Photobiomodulation Therapy Leads a New Generation of Light-Based Therapies for Cancer and Other Complex Diseases: Perspective and Mini Review
Based on existing evidence, it is argued that PBM therapy can improve patients' quality of life and treatment standards at a fraction of the cost of many current approaches. Therefore, PBM therapy could benefit large vulnerable populations, including the elderly and the impoverished, significantly impacting medical practice and public finances.
2016, Caracas, Venezuela, Fundalas Foundation, Interdisciplinary Research and Development Foundation
Tumor Safety and Side Effects of Photobiomodulation Therapy for the Prevention and Management of Cancer Treatment Toxicity: A Systematic Review
Based on the results of this systematic review, PBMT appears to be safe for preventing and/or treating complications associated with cancer treatment.
2019, Piracicaba, São Paulo, Brazil, University of Campinas (UNICAMP), Piracicaba Dental School, Department of Oral Diagnosis
Is Photobiomodulation Effective in Reducing Pain Due to Head and Neck Cancer Treatment Toxicity? A Systematic Review
Despite limited available literature, PBMT appears to be effective in reducing pain and the need for analgesics in patients undergoing HNC treatment.
2019, Piracicaba, São Paulo, Brazil, University of Campinas (UNICAMP), Piracicaba Dental School, Department of Oral Diagnosis, Semiology, and Pathology
Photobiomodulation in the Management of Side Effects Induced by Cancer Treatment: WALT Position Statement 2022
Based on the evidence gathered in this review, PBM has the potential to be a novel option for preventing and/or treating a wide range of acute and chronic side effects related to cancer treatment.
2022, Diepenbeek, Belgium, Hasselt University (UHasselt), Faculty of Medicine and Life Sciences
Photobiomodulation in the Management of Cancer Treatment-Induced Oral Mucositis, Dysphagia, Dry Mouth, Taste Changes, and Oral Burning Sensations: A Case Series
Within the limitations of this study, the specific parameters and treatment protocols used in this study suggest that PBM could be effective in managing cancer treatment-induced oral mucositis, dysphagia, dry mouth, taste changes, and oral burning sensations.
2019, Liège, Belgium, University of Liège, Faculty of Medicine, Department of Dentistry
PBM Therapy for the Alleviation of Cancer Treatment Side Effects
PBM is recognized for reducing inflammation and pain intensity and enhancing wound healing. Many complications associated with cancer treatment, including radiotherapy, chemotherapy, and post-surgical chemoradiotherapy, are closely related to inflammation. Photobiomodulation therapy could be an effective approach for managing cancer treatment side effects.
2020, Nice, France, High-Energy Center, Department of Radiation Oncology
Systematic Review and Clinical Practice Guidelines for PBM in the Management of Oral Mucositis in Cancer Patients
This systematic review supports the efficacy of PBM therapy in preventing oral mucositis (OM).
2019, Tel Hashomer, Israel, Israel Defense Forces Medical Corps, Oral and Maxillofacial Center, Department of Oral Medicine
PBM or Low-Level Laser Therapy for the Management of Oral Mucositis, Dermatitis, and Lymphedema Induced by Cancer Treatment
This paper discusses the mechanisms, dosage, and safety of LLLT/PBM for the treatment of some cancer treatment side effects (oral mucositis, radiation dermatitis, lymphedema) and proposes the use of LLLT/PBM.
2018, Nice, France, High-Energy Center
Low-Level Laser Therapy (PBM) for Breast Cancer-Related Lymphedema: A Systematic Review
Seven high-quality randomized controlled trials (RCTs) were analyzed in eleven clinical studies. LLLT/PBM demonstrated strong evidence for short-term limb circumference/volume reduction, moderate evidence for short-term pain relief, and limited evidence for limb swelling reduction.
2017, Dunedin, New Zealand, University of Otago, School of Physiotherapy, Centre for Health, Activity, and Rehabilitation Research
PBM for the Management of Cancer Treatment-Induced Oral Mucositis: Overview of a Systematic Review
Out of 5,856 references, 16 studies were selected for review. Most studies found that PBMT was effective in preventing and treating oral mucositis (OM), significantly reducing OM severity. The reliability of these results was considered moderate.
2023, Fortaleza, Brazil, Federal University of Ceará, Postgraduate Program in Dentistry
Future Treatment of Oral Mucositis in Cancer Patients: PBM Therapy
PBMT is particularly well received by pediatric patients who have difficulty using mouth rinses. While there are no specific protocols for preventing or treating pediatric oral mucositis, external PBMT is more convenient and less uncomfortable, making it especially suitable for head and neck cancer patients. New guidelines provide preventive protocols for various conditions, and more treatments are expected to be added soon.
2019, Jerusalem, Israel, Hebrew University, Hadassah School of Dental Medicine, Department of Oral Medicine, Sedation and Maxillofacial Imaging, Oral Medicine Clinic for Hematology and Oncology Patients; Israel Defense Forces Medical Corps, Oral and Maxillofacial Center, Department of Oral Medicine
PBM for the Management of Salivary Gland Dysfunction Related to Cancer Treatment: A Systematic Review
Out of 314 articles, five controlled trials were included in this systematic review. Most studies focused on head and neck cancer patients who underwent radiotherapy (RT) or radiochemotherapy (RT-CT), while one study addressed dry mouth related to hematopoietic stem cell transplantation (HSCT). The results for preventing or treating RT- or RT-CT-induced dry mouth or reduced salivary secretion were mixed, whereas the results for HSCT-related dry mouth were positive.
2020, Helsinki, Finland, University of Helsinki, Faculty of Medicine, Department of Oral and Maxillofacial Diseases
PBM for the Prevention and Management of Cancer Treatment Side Effects: Basics, Outcomes, and Prospects
Randomized controlled trials demonstrated that PBM in the red or infrared spectrum effectively managed radiation therapy-related complications, particularly oral mucositis, dermatitis, and upper limb lymphedema. A limitation is that various protocols affect reproducibility. Due to limited research, the evidence level for chemotherapy/radiotherapy effects and graft-versus-host disease remains low. However, safe PBM practice parameters and dosages have been established.
2024, Delmas, Haiti, Saint Paul Health Center, General Medicine; Port-au-Prince, Haiti, Republic University of Haiti
Low-Level Laser Therapy for Oral Mucositis in Children with Cancer
The study results show that LLLT can reduce the severity of oral mucositis and oral pain levels.
2022, Sheffield, UK, University of Sheffield, Department of Oncology and Metabolism
Tumor Safety and Side Effects of PBM for the Prevention and Management of Cancer Treatment Toxicity: A Systematic Review
A total of 27 articles met the search criteria. The selected studies included PBMT for the prevention and treatment of oral mucositis, lymphedema, radiation dermatitis, and peripheral neuropathy. Most studies did not observe adverse effects with PBMT use. Based on the current literature, this systematic review suggests that PBMT does not raise tumor safety concerns in preventing and managing cancer treatment toxicity.
2019, Piracicaba, São Paulo, Brazil, University of Campinas (UNICAMP), Piracicaba Dental School, Department of Oral Diagnosis
Low-Level Laser Therapy/PBM for Managing Chemoradiotherapy Side Effects in Head and Neck Cancer: Part 1 – Mechanism of Action, Dosage Regulation, and Safety Considerations
Based on therapeutic efficacy, PBM using LLLT is safe and may be beneficial for a wide range of HNC treatment complications in the mouth, oropharynx, face, and neck.
2016, Amsterdam, Netherlands, Academic Medical Center, University of Amsterdam, Department of Oral and Maxillofacial Surgery
Potential Applications of PBM in Combined Cancer Therapy: Advances in Diagnosis and Treatment
PBMT acts as a sensitizer for chemotherapy and radiotherapy, protecting non-cancerous cells from cancer treatment toxicity while not reducing survival rates. Proper dosage—wavelength, power density, energy density, and exposure time—is crucial. The World Association for Laser Therapy recommends PBMT for managing cancer treatment-related side effects due to its proven efficacy.
2024, Istanbul, Türkiye, Istinye University, Faculty of Engineering and Natural Sciences, Department of Biology and Genetics
Clinical Use of PBM as an Adjunctive Therapy During Radiotherapy
Randomized controlled trials demonstrated that PBM in the red or infrared spectrum effectively managed radiation therapy-related complications, particularly acute oral mucositis, epithelial damage, and upper limb lymphedema.
2022, Paris, France, Pierre and Marie Curie University, Sorbonne University, Department of Oncology - Radiation Therapy
Effects of PBM Using Low-Power Laser on Breast Cancer Cell Proliferation and Aggressiveness
The study results indicate that PBMT can alter the proliferation of MDA-MB-231 cells and relative levels of NRAS mRNA.
2021, Rio de Janeiro, Brazil, Rio de Janeiro State University, Roberto Alcântara Gomes Institute of Biology, Department of Biophysics and Biometrics
Combination Therapy of PBM and Radiotherapy in a Triple-Negative Breast Cancer Mouse Model
Results showed that PBM halted tumor growth, improved clinical conditions, and prevented hemolytic anemia. Despite the PBM group exhibiting a high neutrophil-to-lymphocyte ratio (NLR), it had fewer lung metastases and increased survival rates.
2021, São Paulo, Brazil, Nuclear and Energy Research Institute (IPEN/CNEN), Center for Lasers and Applications
Clinical Evaluation of PBM in Cancer Patients with Oral Mucositis
Both PBM alone and PBM combined with photodynamic therapy (PDT) significantly reduced oral mucositis (OM) severity (p < 0.01). Additionally, the combination of PDT and PBM resulted in significantly faster healing times compared to PBM alone (p = 0.0321).
2019, Campinas, São Paulo, Brazil, Pontifical Catholic University of Campinas, Faculty of Dentistry
Randomized Placebo-Controlled Trial of PBM for Breast Cancer-Related Lymphedema
In a double-blind, placebo-controlled trial involving 40 patients with unilateral lymphedema, PBMT's effects on pain, quality of life, grip strength, and limb volume differences were evaluated. Patients received 10-minute PBM sessions using a cluster laser covering a beam area of 78.54 cm², delivering 384 joules (4.89 J/cm²). After treatment, median pain scores decreased by 50%, and quality of life improved. Grip strength remained higher than pre-treatment levels after eight PBMT sessions, but there was no significant difference between groups (P > 0.05).
2016, Homburg, Germany, Saarland University, Faculty of Medicine
PBM Using Low-Intensity Laser in Breast and Cervical Cancer Stem Cells
Low-intensity laser irradiation (630–905 nm) has demonstrated remarkable results in various medical applications due to dose-dependent and wavelength-specific effects at the cellular level. This article investigates cellular responses in both healthy and cancerous cells treated with low-intensity laser irradiation, highlighting how different wavelengths and fluences influence therapeutic outcomes, either alone or in combination with photosensitizers in photodynamic therapy.
2017, Johannesburg, South Africa, University of Johannesburg, Faculty of Health Sciences, Laser Research Center
Effects of PBM on the Redox State of Healthy and Cancerous Cells
PBMT reduced SCC-25 ORR by 10% and increased ROS and ATP production in cancer cells after 4 hours, whereas fibroblasts showed a smaller ATP increase after 6 hours. Both cell lines exhibited an increase in G2/M phase cells, with no distinct cell cycle difference. The study suggests that PBMT reduces oxidative stress in oral cancer while affecting normal and tumor cells through different pathways.
2021, São Carlos, São Paulo, Brazil, São Paulo University, Institute of Physics at São Carlos
Safety and Efficacy of PBM in Oncology: A Systematic Review
Of 67 studies, 43 were in vitro, 15 were in vivo, and 9 were clinical trials. The effects of PBMT on cancer cell lines varied due to differences in parameters and frequency of PBM application. In vivo and clinical trials with follow-up confirmed that PBMT is safe for tumor growth and effective in preventing and treating specific cancer therapy complications. Increasing literature supports the safety and efficacy of PBMT, particularly in head and neck cancer (HNC).
2020, Nice, France, High-Energy Center, René-Jean Bensadoun
Laser PBM as a Potential New Frontier in Oral Cancer Treatment: Review of In Vitro and In Vivo Studies
Twelve studies met the inclusion criteria for quality assessment and data extraction. The analysis showed that the clinical application of PBM remains controversial. Some authors suggested that PBM may be contraindicated in SCC patients, while others reported potential benefits.
2021, Rome, Italy, Sapienza University, Department of Oral Sciences and Maxillofacial Surgery
Clinical Application of PBM in Managing Breast Cancer-Related Lymphedema
Out of 24 studies identified on PubMed, seven randomized controlled trials analyzed PBM therapy for BCRL. While some improvements in arm circumference and BCRL symptoms were observed, meta-analysis found no significant advantage in reducing lymphedema.
2021, Cheonan, South Korea, Dankook University, College of Medicine, Department of General Surgery
Long-Term Follow-Up Study on PBM Use for Preventing Acute Radiation Dermatitis in Early-Stage Breast Cancer Patients
PBM did not affect local recurrence, new primary tumor incidence, or overall survival in breast cancer patients receiving CF RT.
2022, Hasselt, Belgium, Hasselt University, Faculty of Medicine and Life Sciences, Limburg Clinical Research Center
Impact of PBM on Weight and BMI in Head and Neck Cancer Patients Undergoing Oral Mucositis Treatment
PBM for oral mucositis helped reduce weight loss and maintain body mass index (BMI) in head and neck cancer patients.
2022, Salvador, Bahia, Brazil, State University of Bahia, Department of Life Sciences
Overview of a Systematic Review on PBM for the Management of Cancer Treatment-Induced Oral Mucositis
Most studies found that PBMT was effective in preventing and treating oral mucositis (OM) and significantly reduced OM severity. The majority of these studies demonstrated moderate reliability.
2023, Fortaleza, Brazil, Federal University of Ceará, Department of Dentistry
Application of Gas Molecules in Cancer Therapy
Gas therapy has rapidly developed in recent years, but only a few gases have reached clinical trials. Some gas molecules, including hydrogen (H₂), nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H₂S), have been found to damage cellular organelles and kill tumor cells. Understanding specific molecular mechanisms is necessary to optimize therapeutic effects.
2023, Wenzhou Medical University, Second Affiliated Hospital & Yuying Children's Hospital, Department of Gastrointestinal Surgery, Wenzhou 325027, China
Role of PBM in Mitigating Cancer Cachexia-Related Muscle Wasting via PI3K/AKT/FoxO3a Pathway Activation
PBMT is emerging as a promising approach for treating cancer-induced muscle atrophy. This study found that PBMT reduced myocyte atrophy in vitro and prevented muscle atrophy in tumor-bearing mice. The protective effects of PBMT were blocked by AKT inhibitors, suggesting that PBMT acts via the PI3K/AKT pathway. In a cisplatin-induced cachexia model, PBMT mitigated muscle wasting, indicating its potential effectiveness in treating cancer-induced muscle loss.
2024, Guangzhou, China, South China Normal University, College of Biophotonics, Laser Life Science Research Institute, Ministry of Education Key Laboratory of Laser Life Science
