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Thesis

Brain-related

A case-control study on the effects of hyperbaric oxygen therapy on patients with cerebral infarction

These results suggest that hyperbaric oxygen therapy (HBOT) could be a useful medical treatment for cerebral infarction. Further studies involving more cases are needed to confirm the definitive effectiveness of HBOT in treating cerebral infarction.
Department of Internal Medicine, Dongseo Oriental Medicine Hospital, Republic of Korea, September 2008.

Hyperbaric oxygen alleviates secondary brain injury after trauma by inhibiting the TLR4/NF-kB signaling pathway

These results suggest that hyperbaric oxygen therapy (HBOT) could be a useful medical treatment for cerebral infarction. Further studies with more cases are necessary to confirm whether HBOT is definitively effective for treating cerebral infarction
Department of Hyperbaric Oxygen, Navy General Hospital, Beijing, China, August 2015

Hyperbaric oxygen inhibits HT22 and PC12 cell damage caused by oxygen-glucose deprivation/reperfusion: suppression of ferroptosis mediated by the Nrf2/System Xc-/GPX4 axis

These parameters were significantly reversed by HBO, indicating that HBO can protect HT22 and PC12 cells from damage induced by oxygen-glucose deprivation/reperfusion. This protection is achieved through the suppression of ferroptosis mediated by the Nrf2/System Xc-/GPX4 axis
Department of Pharmacy, Guangxi Zhuang Autonomous Region and Guangxi People's Hospital, Nanning Medical Research Institute, Guangxi Province, China, September 2022

Hyperbaric oxygen therapy improves Parkinson's disease by promoting mitochondrial biogenesis through the SIRT-1/PGC-1α pathway

The current study provides preliminary evidence suggesting that HBOT treatment can reduce neuroinflammation through the inhibition of the NF-kB signaling pathway and promote neurogenesis via the activation of the CREB/BDNF pathway. Additionally, this therapy has the potential to improve mitochondrial biogenesis through the SIRT-1/PGC-1α-dependent signaling pathway and enhance dopamine function by increasing tyrosine hydroxylase expression. Therefore, our results suggest that HBOT holds potential as an adjunctive therapy in the clinical treatment of Parkinson's disease by protecting dopaminergic neurons
Department of Anesthesiology, Kaohsiung Medical University, Kaohsiung, Taiwan, April 2022

Observation of the effects of oxygen administration on visuospatial cognitive performance using time-course data analysis of fMRI

During visuospatial tasks, high-concentration oxygen administration sufficiently enhances oxygen supply, leading to greater activation of neural networks and improved performance in visuospatial tasks
Department of Biomedical Science and Engineering, Konkuk University, March 2005

Hyperbaric oxygen therapy improves neurocognitive function in post-stroke patients – a retrospective analysis

HBOT induces significant improvements in all cognitive domains, even in the chronic phase following a stroke. When selecting stroke patients for HBOT, decisions should be based on functional assessment and baseline cognitive scores rather than the type, location, or side of the stroke lesion
Department of Neurosurgery, Galilee Medical Center, Nahariya, Israel, January 2020

Systematic review and dose-response analysis: the effects of hyperbaric oxygen therapy in persistent post-concussion syndrome following mild traumatic brain injury

Several randomized and randomized controlled trials have shown that HBOT at 1.5 ATA oxygen produces statistically significant results in symptomatic and cognitive improvements in patients with persistent post-concussion syndrome following mild traumatic brain injury
Department of Emergency Medicine, Division of Hyperbaric Medicine, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA, 2022

Hyperbaric oxygen therapy for persistent post-concussion syndrome following mild traumatic brain injury: a randomized controlled trial

Most improvements from HBOT were sustained, with some tests showing continued improvement nearly three months after the final HBOT session. This suggests that HBOT could be proposed as a disease-modifying treatment for mTBI-related persistent post-concussion syndrome (PPCS)
Department of Emergency and Hyperbaric Medicine, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA, 2019

Review of the neuroprotective effects of hyperbaric oxygen therapy

The evidence presented in this review indicates that HBOT has potential for the treatment and prevention of various types of neurological damage
Molecular and Cellular Biology Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, 2020

The effects of high-concentration oxygen administration on additional task performance and physiological signals

This study demonstrated that high-concentration oxygen supply increases blood oxygen saturation, accelerating brain activation from cognitive processes and enhancing arithmetic abilities. The effect of high-concentration oxygen becomes particularly significant when task difficulty increases, as oxygen demand rises accordingly
Department of Biomedical Science and Engineering, Biomedical Science and Technology Research Institute, Konkuk University, 2008

Case Report: Treatment of ADHD and Learning Disabilities with Hyperbaric Oxygen Therapy and Eastern Medicine

Therapies, including hyperbaric oxygen therapy, were found to be effective in treating ADHD and learning disabilities.
2013, Dongseo Korean Medicine Clinic, Korean Neuropsychiatric Association