Thesis
Brain-related
The beneficial effects of hydrogen gas through the reduction of oxidative stress in a rat model of traumatic brain injury
Rats with traumatic brain injury (TBI) showed increased BBB permeability, brain edema, lesion volume, and neurological dysfunction, indicating severe brain damage, all of which were significantly reduced by 2% H₂ treatment. Furthermore, the reduction in oxidative products and the increase in endogenous antioxidant enzyme activity in brain tissue suggest that the protective effects of H₂ treatment are associated with these changes in TBI-challenged rats. This study suggests that H₂ inhalation could be a more effective therapeutic strategy for TBI patients
Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China, 710032, 2010
The Effect of Hydrogen Gas Inhalation on Reducing Infarct Size in a Rat Model of Myocardial Ischemia-Reperfusion Injury
Inhalation of H₂ gas at a non-combustible level during ischemia and reperfusion reduces infarct size without altering hemodynamic parameters, helping to prevent harmful left ventricular remodeling. Therefore, H₂ gas inhalation is a promising approach to mitigate ischemia-reperfusion injury associated with coronary artery reperfusion
2008, Keio University School of Medicine, Department of Cardiology, Tokyo 160-8582, Japan
Hydrogen Gas Inhalation Therapy for Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection
The H₂ group showed no significant adverse effects and demonstrated improvements in oxygen saturation. Key findings included changes in relative signal intensity on MRI, which reflects the severity of the infarct area, improvements in NIHSS scores that clinically quantify stroke severity, and better physical therapy outcomes as measured by the Barthel Index. Thus, H₂ therapy was safe and effective for patients with acute cerebral infarction
2017, Department of Neurosurgery, Nishijima Hospital, Numazu City, Shizuoka, Japan
The Effect of Molecular Hydrogen Inhalation on Alleviating Postoperative Cognitive Dysfunction
Adult male rats inhaled 2% hydrogen gas for 3 hours starting 1 hour after undergoing stabilized tibial fracture surgery. Cognitive assessments using fear conditioning and Y-maze tests revealed significant surgery-induced impairments, which were notably improved by H₂ treatment. This therapy reduced inflammatory cytokines (TNF-α, IL-1β, IL-6, HMGB1) in the serum and hippocampus, enhanced blood-brain barrier integrity, and decreased caspase-3 activity in the hippocampus. These results demonstrate that H₂ effectively mitigates cognitive deficits by reducing postoperative inflammation and apoptosis
2017, Department of Anesthesiology and Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China, and Department of Respiratory and Critical Care Medicine
Study on the Protective Effect of Hydrogen Gas Therapy After Gonadal Hemorrhage in Neonatal Mice
Hydrogen gas inhalation is an effective method to protect the brain of infants from post-hemorrhage effects that lead to brain atrophy, intellectual disability, and cerebral palsy
2011, Department of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA
The Effect of High-Concentration Hydrogen Gas Inhalation on Reducing Cognitive Deficits in an Asphyxia-Induced Cardiac Arrest Rat Model
According to the study results, 67% hydrogen gas generated by water electrolysis could be a promising therapeutic strategy for improving cognitive outcomes related to global brain hypoxia-ischemia following cardiac arrest
2019, Department of Neurosurgery, School of Medicine, Loma Linda University, Loma Linda, California, USA
The Effect of Molecular Hydrogen on Alleviating Brain Injury and Cognitive Impairment in a Chronic Sequelae Model of Polymicrobial Sepsis
According to the study results, H₂ therapy improved survival rates, alleviated cognitive deficits, reduced histological damage in the hippocampus, and decreased Evans blue (EB) and water content. Additionally, H₂ therapy reduced the levels of TNF-α, IL-6, HMGB1, Nrf2, HO-1, ZO-1, and Occludin compared to the SAE group
2020, Department of Anesthesiology, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin, People's Republic of China
Study on the Role of Molecular Hydrogen as a Neuroprotective Agent
Most neurological diseases are currently incurable, but these studies suggest the clinical potential of H₂ administration for their prevention, treatment, and mitigation. The potential mechanisms of H₂, including the cell signaling molecules and hormones responsible for preventing oxidative stress and inflammation, will also be discussed. Nevertheless, further investigation is needed to identify the direct target molecules of H₂
2017, Biological Aging Process, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
The Effect of Chronic Molecular Hydrogen Inhalation on Alleviating Short-Term and Long-Term Memory Loss in Polymicrobial Sepsis
Our research findings suggest that (1) prolonged exposure to hydrogen gas is a simple, safe, and effective therapeutic approach to prevent memory loss in sepsis patients, and (2) short-term H₂ inhalation reduces neuroinflammation in brain regions associated with memory and increases the expression of nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2 is a transcription factor that regulates the expression of various antioxidant and anti-inflammatory agents in these regions of septic animals
2020, Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil
The Effect of Hydrogen Gas on Improving Sepsis-Induced Brain Injury in Rats: A Study on Enhancing Mitochondrial Biogenesis via PGC-α Activation
The current study demonstrated that hydrogen gas therapy improved 7-day survival rates, enhanced cognitive function, and improved mitochondrial function, as evidenced by increased mitochondrial membrane potential (MMP), ATP levels, and complex I activity. Additionally, the study showed an upregulation in the expression of mitochondrial biogenesis markers, including PGC-1α, NRF2, and Tfam
2021, Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China
Molecular Hydrogen as a Novel Therapeutic Approach for Stroke Management
Molecular hydrogen contributes to antioxidant, anti-inflammatory, and anti-apoptotic activities in normal
2023, Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
The Effect of Hydrogen Inhalation on Neuroprotection and Functional Outcome Improvement After Intracerebral Hemorrhage
According to the study results, hydrogen gas inhalation provides immediate protection to the brain in a mouse model of intracerebral hemorrhage (ICH)
2011, Department of Physiology and Pharmacology, School of Medicine, Loma Linda University, Loma Linda, USA
Neuroprotective Effect of Hydrogen Inhalation in an Experimental Intracerebral Hemorrhage Model
H₂ gas administration exhibits anti-inflammatory, neuroprotective, anti-apoptotic, and antioxidant effects, providing neuroprotection against early brain injury following intracerebral hemorrhage (ICH)
2018, Department of Neurosurgery, Hanyang University College of Medicine
Study on the Effect of Hydrogen Gas Inhalation on L-DOPA-Induced Dyskinesia
Hydrogen gas (H₂) exhibits neuroprotective and anti-inflammatory effects in Parkinson's disease models. H₂ inhalation reduced microglial activation and inflammatory cytokines in the striatum, which was associated with a decrease in abnormal involuntary movements. This reduction is linked to decreased inflammation both in the striatum and peripherally. These findings highlight the potential of H₂ to improve the well-being of Parkinson's disease patients treated with L-DOPA.
2023, Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Brazil
The effects of molecular hydrogen on alleviating lung injury after traumatic brain injury: a study on apoptosis and autophagy
H₂ promotes the recovery of acute lung injury (ALI) induced by traumatic brain injury (TBI) by reducing apoptosis and autophagy, as well as mitigating inflammation. These findings provide guidance and support for the use of H₂ in treating ALI patients with TBI in the intensive care unit (ICU)
Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, 246 XueFu Road, NanGang District, Harbin, China, 2022
The effects of hydrogen gas inhalation on alleviating early brain injury and improving delayed brain injury following experimental subarachnoid hemorrhage
Molecular hydrogen (H₂) protects neurons from reactive oxygen species and alleviates early brain injury (EBI) following subarachnoid hemorrhage (SAH)
Department of Neurosurgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan, 2010
The role of hydrogen as a therapeutic antioxidant that selectively reduces cytotoxic oxygen radicals
H₂ gas inhalation significantly reduced brain damage by counteracting the effects of oxidative stress. Due to its ability to rapidly diffuse across membranes, H₂ can neutralize cytotoxic reactive oxygen species (ROS) and prevent oxidative damage, making it an effective therapeutic antioxidant
Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1-396 Kosugicho, Nakahara-ku, Kawasaki, Japan, 211-8533, 2007
The effects of hydrogen inhalation on the suppression of microglial activation and neuroinflammation in a rat model of traumatic brain injury
The study results indicate that hydrogen may provide protective effects against traumatic brain injury (TBI) by reducing microglial activation and neuroinflammation
School of Life Science and Biotechnology, Beijing Institute of Technology, Beijing Molecular Hydrogen Research Center, Beijing 100124, China, 2020
A new promising therapy of hydrogen gas for emergency and critical care medicine
In the near future, hydrogen gas could be administered to patients in ambulances, made available through standard wall outlets in hospitals, and provided for inhalation at home after discharge
Department of Cardiology, Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan, September 2017
Molecular hydrogen inhibits glioblastoma growth and induces differentiation of glioblastoma stem cells
The current study shows that 67% hydrogen gas inhalation has an inhibitory effect on GBM. Both in vivo and in vitro studies demonstrated that molecular hydrogen can induce desirable differentiation of GSCs. Furthermore, molecular hydrogen suppresses the migration, invasion, and colony formation abilities of GBM cells
School of Life Science and Biotechnology, Peking University, Beijing 100124, China, May 2019
A randomized controlled trial on the efficacy of inhaled hydrogen for cerebral ischemia during post-cardiac arrest treatment (HYBRID II trial) study protocol
The unique features of hydrogen inhalation (HI) include its minimally invasive nature, ease and safety of administration, and the absence of known adverse effects. Therefore, if H₂ is proven effective, HI is expected to have the potential for widespread application in post-cardiac arrest syndrome (PCAS) patients
Department of Emergency Medicine and Critical Care, Keio University, 2015
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases
The effects of hydrogen have been reported in 63 disease models and human diseases (see Table 1). Only stroke and metabolic syndrome have been analyzed in both rodents and humans. Since no adverse effects of hydrogen have been observed, clinical studies are feasible even in the absence of animal research. Several other human studies, including those on Parkinson's disease, are currently underway, and hydrogen is expected to show promising effects on many other human diseases. The molecular basis of hydrogen's effects also needs to be further elucidated
Department of Neurogenetics, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa-ku, Nagoya 466-8550, Japan, 2012
Hydrogen Inhalation Mitigates Mast Cell-Mediated Brain Damage Caused by ICH in Mice
Hydrogen inhalation reduced mast cell activation and degranulation, alleviating ICH-induced brain edema and neurological deficits in mice.
2014, Department of Physiology and Pharmacology, Loma Linda University Medical Center, Loma Linda, California, USA
