관련 논문 (뇌) – HueLight

Related Papers

Thesis

Brain-related

The effects of whole-body vibration exercise on intracerebral hemorrhage in rats.

This study demonstrated that whole-body vibration exercise inhibits apoptotic neuronal death induced by intracerebral hemorrhage, thereby promoting the recovery of brain function after intracerebral hemorrhage.
Department of Exercise Physiology, Graduate School of Korea University, May 2012

A case-control study on the effects of hyperbaric oxygen therapy on patients with cerebral infarction

These results suggest that hyperbaric oxygen therapy (HBOT) could be a useful medical treatment for cerebral infarction. Further studies involving more cases are needed to confirm the definitive effectiveness of HBOT in treating cerebral infarction.
Department of Internal Medicine, Dongseo Oriental Medicine Hospital, Republic of Korea, September 2008.

Hyperbaric oxygen alleviates secondary brain injury after trauma by inhibiting the TLR4/NF-kB signaling pathway

These results suggest that hyperbaric oxygen therapy (HBOT) could be a useful medical treatment for cerebral infarction. Further studies with more cases are necessary to confirm whether HBOT is definitively effective for treating cerebral infarction
Department of Hyperbaric Oxygen, Navy General Hospital, Beijing, China, August 2015

Hyperbaric oxygen inhibits HT22 and PC12 cell damage caused by oxygen-glucose deprivation/reperfusion: suppression of ferroptosis mediated by the Nrf2/System Xc-/GPX4 axis

These parameters were significantly reversed by HBO, indicating that HBO can protect HT22 and PC12 cells from damage induced by oxygen-glucose deprivation/reperfusion. This protection is achieved through the suppression of ferroptosis mediated by the Nrf2/System Xc-/GPX4 axis
Department of Pharmacy, Guangxi Zhuang Autonomous Region and Guangxi People's Hospital, Nanning Medical Research Institute, Guangxi Province, China, September 2022

Hyperbaric oxygen therapy improves Parkinson's disease by promoting mitochondrial biogenesis through the SIRT-1/PGC-1α pathway

The current study provides preliminary evidence suggesting that HBOT treatment can reduce neuroinflammation through the inhibition of the NF-kB signaling pathway and promote neurogenesis via the activation of the CREB/BDNF pathway. Additionally, this therapy has the potential to improve mitochondrial biogenesis through the SIRT-1/PGC-1α-dependent signaling pathway and enhance dopamine function by increasing tyrosine hydroxylase expression. Therefore, our results suggest that HBOT holds potential as an adjunctive therapy in the clinical treatment of Parkinson's disease by protecting dopaminergic neurons
Department of Anesthesiology, Kaohsiung Medical University, Kaohsiung, Taiwan, April 2022

Observation of the effects of oxygen administration on visuospatial cognitive performance using time-course data analysis of fMRI

During visuospatial tasks, high-concentration oxygen administration sufficiently enhances oxygen supply, leading to greater activation of neural networks and improved performance in visuospatial tasks
Department of Biomedical Science and Engineering, Konkuk University, March 2005

Hyperbaric oxygen therapy improves neurocognitive function in post-stroke patients – a retrospective analysis

HBOT induces significant improvements in all cognitive domains, even in the chronic phase following a stroke. When selecting stroke patients for HBOT, decisions should be based on functional assessment and baseline cognitive scores rather than the type, location, or side of the stroke lesion
Department of Neurosurgery, Galilee Medical Center, Nahariya, Israel, January 2020

Systematic review and dose-response analysis: the effects of hyperbaric oxygen therapy in persistent post-concussion syndrome following mild traumatic brain injury

Several randomized and randomized controlled trials have shown that HBOT at 1.5 ATA oxygen produces statistically significant results in symptomatic and cognitive improvements in patients with persistent post-concussion syndrome following mild traumatic brain injury
Department of Emergency Medicine, Division of Hyperbaric Medicine, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA, 2022

Hyperbaric oxygen therapy for persistent post-concussion syndrome following mild traumatic brain injury: a randomized controlled trial

Most improvements from HBOT were sustained, with some tests showing continued improvement nearly three months after the final HBOT session. This suggests that HBOT could be proposed as a disease-modifying treatment for mTBI-related persistent post-concussion syndrome (PPCS)
Department of Emergency and Hyperbaric Medicine, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA, 2019

Review of the neuroprotective effects of hyperbaric oxygen therapy

The evidence presented in this review indicates that HBOT has potential for the treatment and prevention of various types of neurological damage
Molecular and Cellular Biology Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, 2020

The effects of high-concentration oxygen administration on additional task performance and physiological signals

This study demonstrated that high-concentration oxygen supply increases blood oxygen saturation, accelerating brain activation from cognitive processes and enhancing arithmetic abilities. The effect of high-concentration oxygen becomes particularly significant when task difficulty increases, as oxygen demand rises accordingly
Department of Biomedical Science and Engineering, Biomedical Science and Technology Research Institute, Konkuk University, 2008

The beneficial effects of hydrogen gas through the reduction of oxidative stress in a rat model of traumatic brain injury

Rats with traumatic brain injury (TBI) showed increased BBB permeability, brain edema, lesion volume, and neurological dysfunction, indicating severe brain damage, all of which were significantly reduced by 2% H₂ treatment. Furthermore, the reduction in oxidative products and the increase in endogenous antioxidant enzyme activity in brain tissue suggest that the protective effects of H₂ treatment are associated with these changes in TBI-challenged rats. This study suggests that H₂ inhalation could be a more effective therapeutic strategy for TBI patients
Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China, 710032, 2010

The Effect of Hydrogen Gas Inhalation on Reducing Infarct Size in a Rat Model of Myocardial Ischemia-Reperfusion Injury

Inhalation of H₂ gas at a non-combustible level during ischemia and reperfusion reduces infarct size without altering hemodynamic parameters, helping to prevent harmful left ventricular remodeling. Therefore, H₂ gas inhalation is a promising approach to mitigate ischemia-reperfusion injury associated with coronary artery reperfusion
2008, Keio University School of Medicine, Department of Cardiology, Tokyo 160-8582, Japan

Hydrogen Gas Inhalation Therapy for Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection

The H₂ group showed no significant adverse effects and demonstrated improvements in oxygen saturation. Key findings included changes in relative signal intensity on MRI, which reflects the severity of the infarct area, improvements in NIHSS scores that clinically quantify stroke severity, and better physical therapy outcomes as measured by the Barthel Index. Thus, H₂ therapy was safe and effective for patients with acute cerebral infarction
2017, Department of Neurosurgery, Nishijima Hospital, Numazu City, Shizuoka, Japan

The Effect of Molecular Hydrogen Inhalation on Alleviating Postoperative Cognitive Dysfunction

Adult male rats inhaled 2% hydrogen gas for 3 hours starting 1 hour after undergoing stabilized tibial fracture surgery. Cognitive assessments using fear conditioning and Y-maze tests revealed significant surgery-induced impairments, which were notably improved by H₂ treatment. This therapy reduced inflammatory cytokines (TNF-α, IL-1β, IL-6, HMGB1) in the serum and hippocampus, enhanced blood-brain barrier integrity, and decreased caspase-3 activity in the hippocampus. These results demonstrate that H₂ effectively mitigates cognitive deficits by reducing postoperative inflammation and apoptosis
2017, Department of Anesthesiology and Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China, and Department of Respiratory and Critical Care Medicine

Study on the Protective Effect of Hydrogen Gas Therapy After Gonadal Hemorrhage in Neonatal Mice

Hydrogen gas inhalation is an effective method to protect the brain of infants from post-hemorrhage effects that lead to brain atrophy, intellectual disability, and cerebral palsy
2011, Department of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA

The Effect of High-Concentration Hydrogen Gas Inhalation on Reducing Cognitive Deficits in an Asphyxia-Induced Cardiac Arrest Rat Model

According to the study results, 67% hydrogen gas generated by water electrolysis could be a promising therapeutic strategy for improving cognitive outcomes related to global brain hypoxia-ischemia following cardiac arrest
2019, Department of Neurosurgery, School of Medicine, Loma Linda University, Loma Linda, California, USA

The Effect of Molecular Hydrogen on Alleviating Brain Injury and Cognitive Impairment in a Chronic Sequelae Model of Polymicrobial Sepsis

According to the study results, H₂ therapy improved survival rates, alleviated cognitive deficits, reduced histological damage in the hippocampus, and decreased Evans blue (EB) and water content. Additionally, H₂ therapy reduced the levels of TNF-α, IL-6, HMGB1, Nrf2, HO-1, ZO-1, and Occludin compared to the SAE group
2020, Department of Anesthesiology, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin, People's Republic of China

Study on the Role of Molecular Hydrogen as a Neuroprotective Agent

Most neurological diseases are currently incurable, but these studies suggest the clinical potential of H₂ administration for their prevention, treatment, and mitigation. The potential mechanisms of H₂, including the cell signaling molecules and hormones responsible for preventing oxidative stress and inflammation, will also be discussed. Nevertheless, further investigation is needed to identify the direct target molecules of H₂
2017, Biological Aging Process, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan

The Effect of Chronic Molecular Hydrogen Inhalation on Alleviating Short-Term and Long-Term Memory Loss in Polymicrobial Sepsis

Our research findings suggest that (1) prolonged exposure to hydrogen gas is a simple, safe, and effective therapeutic approach to prevent memory loss in sepsis patients, and (2) short-term H₂ inhalation reduces neuroinflammation in brain regions associated with memory and increases the expression of nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2 is a transcription factor that regulates the expression of various antioxidant and anti-inflammatory agents in these regions of septic animals
2020, Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil

The Effect of Hydrogen Gas on Improving Sepsis-Induced Brain Injury in Rats: A Study on Enhancing Mitochondrial Biogenesis via PGC-α Activation

The current study demonstrated that hydrogen gas therapy improved 7-day survival rates, enhanced cognitive function, and improved mitochondrial function, as evidenced by increased mitochondrial membrane potential (MMP), ATP levels, and complex I activity. Additionally, the study showed an upregulation in the expression of mitochondrial biogenesis markers, including PGC-1α, NRF2, and Tfam
2021, Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China

Molecular Hydrogen as a Novel Therapeutic Approach for Stroke Management

Molecular hydrogen contributes to antioxidant, anti-inflammatory, and anti-apoptotic activities in normal
2023, Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan

The Effect of Hydrogen Inhalation on Neuroprotection and Functional Outcome Improvement After Intracerebral Hemorrhage

According to the study results, hydrogen gas inhalation provides immediate protection to the brain in a mouse model of intracerebral hemorrhage (ICH)
2011, Department of Physiology and Pharmacology, School of Medicine, Loma Linda University, Loma Linda, USA

Neuroprotective Effect of Hydrogen Inhalation in an Experimental Intracerebral Hemorrhage Model

H₂ gas administration exhibits anti-inflammatory, neuroprotective, anti-apoptotic, and antioxidant effects, providing neuroprotection against early brain injury following intracerebral hemorrhage (ICH)
2018, Department of Neurosurgery, Hanyang University College of Medicine

Study on the Effect of Hydrogen Gas Inhalation on L-DOPA-Induced Dyskinesia

Hydrogen gas (H₂) exhibits neuroprotective and anti-inflammatory effects in Parkinson's disease models. H₂ inhalation reduced microglial activation and inflammatory cytokines in the striatum, which was associated with a decrease in abnormal involuntary movements. This reduction is linked to decreased inflammation both in the striatum and peripherally. These findings highlight the potential of H₂ to improve the well-being of Parkinson's disease patients treated with L-DOPA.
2023, Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Brazil

The effects of molecular hydrogen on alleviating lung injury after traumatic brain injury: a study on apoptosis and autophagy

H₂ promotes the recovery of acute lung injury (ALI) induced by traumatic brain injury (TBI) by reducing apoptosis and autophagy, as well as mitigating inflammation. These findings provide guidance and support for the use of H₂ in treating ALI patients with TBI in the intensive care unit (ICU)
Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, 246 XueFu Road, NanGang District, Harbin, China, 2022

The effects of hydrogen gas inhalation on alleviating early brain injury and improving delayed brain injury following experimental subarachnoid hemorrhage

Molecular hydrogen (H₂) protects neurons from reactive oxygen species and alleviates early brain injury (EBI) following subarachnoid hemorrhage (SAH)
Department of Neurosurgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan, 2010

The role of hydrogen as a therapeutic antioxidant that selectively reduces cytotoxic oxygen radicals

H₂ gas inhalation significantly reduced brain damage by counteracting the effects of oxidative stress. Due to its ability to rapidly diffuse across membranes, H₂ can neutralize cytotoxic reactive oxygen species (ROS) and prevent oxidative damage, making it an effective therapeutic antioxidant
Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1-396 Kosugicho, Nakahara-ku, Kawasaki, Japan, 211-8533, 2007

The effects of hydrogen inhalation on the suppression of microglial activation and neuroinflammation in a rat model of traumatic brain injury

The study results indicate that hydrogen may provide protective effects against traumatic brain injury (TBI) by reducing microglial activation and neuroinflammation
School of Life Science and Biotechnology, Beijing Institute of Technology, Beijing Molecular Hydrogen Research Center, Beijing 100124, China, 2020

A new promising therapy of hydrogen gas for emergency and critical care medicine

In the near future, hydrogen gas could be administered to patients in ambulances, made available through standard wall outlets in hospitals, and provided for inhalation at home after discharge
Department of Cardiology, Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan, September 2017

Molecular hydrogen inhibits glioblastoma growth and induces differentiation of glioblastoma stem cells

The current study shows that 67% hydrogen gas inhalation has an inhibitory effect on GBM. Both in vivo and in vitro studies demonstrated that molecular hydrogen can induce desirable differentiation of GSCs. Furthermore, molecular hydrogen suppresses the migration, invasion, and colony formation abilities of GBM cells
School of Life Science and Biotechnology, Peking University, Beijing 100124, China, May 2019

A randomized controlled trial on the efficacy of inhaled hydrogen for cerebral ischemia during post-cardiac arrest treatment (HYBRID II trial) study protocol

The unique features of hydrogen inhalation (HI) include its minimally invasive nature, ease and safety of administration, and the absence of known adverse effects. Therefore, if H₂ is proven effective, HI is expected to have the potential for widespread application in post-cardiac arrest syndrome (PCAS) patients
Department of Emergency Medicine and Critical Care, Keio University, 2015

Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases

The effects of hydrogen have been reported in 63 disease models and human diseases (see Table 1). Only stroke and metabolic syndrome have been analyzed in both rodents and humans. Since no adverse effects of hydrogen have been observed, clinical studies are feasible even in the absence of animal research. Several other human studies, including those on Parkinson's disease, are currently underway, and hydrogen is expected to show promising effects on many other human diseases. The molecular basis of hydrogen's effects also needs to be further elucidated
Department of Neurogenetics, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa-ku, Nagoya 466-8550, Japan, 2012

Photobiomodulation (PBM) enhances the survival of nigral dopaminergic cells in a chronic MPTP mouse model of Parkinson's disease

Exposure to PBM protected a significant number of substantia nigra pars compacta (SNc) dopaminergic cells from degeneration, even when applied concurrently with or after chronic MPTP exposure
Department of Anatomy and Histology, F13, University of Sydney, Australia, 2012

Near-infrared light therapy alleviates Alzheimer's disease-related pathology in two transgenic mouse models – evidence from the cerebral cortex

This study explores the effects of near-infrared (NIr) light therapy in two Alzheimer's disease (AD) mouse models: the K369I tau mutant (K3) and the APPswe/PSEN1dE9 mutant (APP/PS1). Over a period of 4 weeks, NIr therapy significantly reduced neurofibrillary tangles and oxidative stress markers in K3 mice, and decreased amyloid-beta plaques in APP/PS1 mice. These findings suggest that NIr therapy can alleviate and potentially reverse AD-related brain degeneration through a non-invasive approach
Department of Physiology, University of Sydney, Anderson Stuart Building F13, NSW 2006, Australia, 2014

Near-infrared light energy penetration: Can infrared light therapy effectively reach the human brain?

This review demonstrates that near-infrared light at wavelengths of 810 nm and 980 nm, with an output range of 10-15 W, has been shown to be biologically beneficial at a depth of 3 cm. This confirms that near-infrared light can penetrate to a depth of 3 cm, which is sufficient to reach the skull and brain
Synaptic Space, Centennial, Colorado, USA, 2015

Photobiomodulation (PBM) suppresses alpha-synuclein-induced toxicity in an AAV-based genetic model of Parkinson's disease

Exposing both sides of the rats' heads to 808-nm near-infrared light daily for 28 consecutive days significantly alleviated alpha-synuclein-induced motor impairments, as assessed by the cylinder test. This treatment also notably reduced the loss of dopaminergic neurons in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. These beneficial effects persisted for at least 6 weeks after the treatment was discontinued
Institute of Molecular and Chemical Biology of Neurodegeneration, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne, Switzerland, and Center de Recherche du Centre Hospitalier de Québec, Ax Neuroscience and Department of Molecular Medicine, Laval University, Quebec, G1V4G2, Canada, 2015

810nm near-infrared light provides neuroprotection and improves motor activity in MPTP-treated mice

The study results showed that MPTP-treated mice exposed to 810 nm near-infrared (NIr) light had approximately 40% greater motor activity and about 20% more dopaminergic neurons compared to non-exposed mice. In summary, 810 nm NIr, similar to 670 nm NIr, provided neuroprotective effects and improved motor activity in MPTP-treated mice
CLINATEC, EJ Safra Centre, CEA, LETI, Grenoble University, Alpes F38000, France, 2015

Near-infrared light therapy reduces astrogliosis in MPTP-treated monkeys

The study results showed that PBM treatment significantly reduced MPTP-induced astrogliosis by approximately 75% in both the SNc and striatum. However, for microglia, PBM had a more limited effect in both nuclei; while the overall size of the cells decreased, the number of microglia remained unchanged in MPTP-treated monkeys following PBM treatment
Department of Anatomy, University of Sydney, F13, Sydney, 2006, Australia, 2016

PBM-induced changes in a Parkinson's disease monkey model: alterations in tyrosine hydroxylase cells and GDNF expression in the striatum

This study investigated the effects of photobiomodulation (PBM) on tyrosine hydroxylase (TH) positive cells and GDNF expression in the hypothalamus. Analysis of hypothalamic slices from MPTP-treated mice, monkeys, and 6OHDA-lesioned rats showed that PBM significantly increased TH-positive cells and GDNF levels by 60-80% in MPTP-treated monkeys compared to controls. However, these increases were not observed in the less damaged mouse and rat models. This suggests that PBM's therapeutic effect is primarily associated with enhancing trophic factors like GDNF in conditions with pronounced dopaminergic loss
Department of Anatomy, University of Sydney, F13, Sydney, 2006, Australia, 2016

Brain PBM Therapy: A Descriptive Review

Brain PBM therapy enhances the metabolic capacity of neurons, promotes anti-inflammatory, anti-apoptotic, and antioxidant responses, and aids in neurogenesis and synaptogenesis. Interest in PBM therapy for the treatment of conditions such as dementia, Parkinson's disease, stroke, brain injury, and depression is steadily increasing
2018 Tabriz University of Medical Sciences, Neuroscience Research Center (NSRC), Tabriz, Iran

Photobiomodulation Therapy for Traumatic Brain Injury and Stroke

PBM uses red or near-infrared light to promote healing, enhance mitochondrial function, and improve blood flow and oxygen supply. It also reduces swelling and inflammation, decreases cell death, and promotes neurogenesis and synaptogenesis to aid brain recovery. Both animal experiments and human studies, including those involving patients with chronic traumatic brain injury (TBI), have shown improvements in neurological function, memory, mood, and cognitive abilities
2018 Harvard Medical School, Department of Dermatology

파킨슨 병을 대상으로한 PBM: 무작위 대조 시험

이 연구는 인간의 머리, 코, 목, 복부에 복합 빛생물조절 치료를 적용하면 파킨슨병의 일부 임상적 및 비운동 증상을 감소시키거나 역전시킬 수 있는 잠재력이 있음을 나타냈다.
2019년 스페인 레온 레온 대학교 체육 및 스포츠학과; 성과 및 건강 그룹, 체육 및 스포츠학과, 아 코루냐 대학교, 아 코루냐, 스페인

"Photobiomics": PBM을 포함한 빛이 미생물체를 변화시킬 수 있을까?

장내 미생물군의 구성과 건강이 대사 관련 질환, 비만, 심혈관 장애, 자가면역 질환, 심지어 뇌 질환에 영향을 미친다는 것이 알려져 있다. 빛이 미생물군에 미치는 영향에 대한 연구 보고서를 찾기 위해 문헌 검색이 수행되었다. 최근 연구에서는 PBM(적색 및 근적외선)이 마우스의 복부에 조사될 때 장내 미생물군을 잠재적으로 유익한 방식으로 변화시킬 수 있다는 것이 밝혀졌다. 이 효과는 이제 인간 대상에서도 관찰되었다.
2019년 호주 와룽가 소재 호주연구소.시드니대학교 의과대학, 캠퍼다운, 호주

남성 스프라그 도리 랫트에서 지질다당류 유도 도파민성 세포 손실을 구제하는 PBM의 효과

이 연구에서 PBM이 낮은 LPS 용량(10 µg)에서 흔히 발생하는 15%의 세포 사멸을 유발하는 신경 손실로부터 쥐를 보호했다는 것을 발견했다. 그러나 PBM은 더 높은 LPS 용량(20 µg)에서 덜 효과적이었다; 이 용량은 50%의 세포 사멸과 증가된 염증성 미세아교세포를 초래한다. 또한, PBM은 더 높은 LPS 용량에서 운동 장애와 병변 크기 사이의 연결을 방해했다는 것을 보여주었는데, 이는 흑질 기저부를 넘어서 잠재적인 운동 기능 개선을 시사한다. 전반적으로, 이 결과는 PBM이 초기 단계 PD에 대한 유망한 신경보호 치료법이라는 것을 나타내며, 특히 염증이 중간 정도일 때 그렇다. 또한, PBM은 영향을 받은 회로에서 운동 기능을 개선하는 데 도움이 될 수도 있다.
2019년 해부학 및 조직학 분야, 의과대학, 의과대학, 시드니 대학교, NSW 2006, 호주

알츠하이머 치매 및 파킨슨병 치료: PBM과 신경 피드백 통합 검토

PBM 치료를 받은 대상자들은 활성 치료를 받은 사람들이 시계 그리기, 즉각적인 기억 회상, 실용적인 기억, 시각적 주의 및 과제 전환(Trails A & B)과 같은 집행 기능에서 더 큰 향상을 보이는 경향이 있었다.
2019년 콰이어트마인드 재단, 펜실베니아 주 엘킨스 파크, 미국

파킨슨병 신경독성 MPTP에 의해 유발된 뇌혈관 누출 완화를 위한 PBM

이 연구는 저강도 적색광을 사용하는 광생물자극(PBM)이 마우스에서 MPTP에 의해 유발된 뇌혈관 손상을 효과적으로 감소시킨다는 것을 보여주었다. MPTP를 투여한 후, 뇌 영역인 흑질 기저부(SNc)와 대뇌측핵복합체(CPu)에서 상당한 혈관 누출이 관찰되었다. 그러나 PBM으로 처리된 마우스는 이러한 영역에서 현저히 감소된 누출을 보였으며, 그 수준은 생리식염수를 주입한 대조군과 비슷했다. 이 결과는 PBM이 파킨슨병과 같은 신경 장애에서 혈관 기능 장애를 완화할 수 있는 잠재력을 강조한다.
2019년 생리학 분야 및 보쉬 연구소, 시드니 대학교, 시드니, NSW 2006, 호주

뇌 노화에 대한 PBM

연구에 따르면 광생물조절 치료(PBM)는 뇌의 대사와 혈류를 개선하고 미토콘드리아 기능 및 혈관 건강을 증진시킨다. 인간을 대상으로 한 연구에서는 특히 노인의 주의력, 학습, 기억력, 기분과 같은 인지 기능을 향상시키는 것으로 나타났다.
2021년 텍사스대, 심리학과와 뇌과학 연구소

중추신경계 질환에서 PBM의 현재 적용과 미래 방향

이 연구에서는 총 95편의 논문을 검토하여 광생물자극(PBM)이 뇌졸중, 외상성 뇌 손상, 파킨슨병, 알츠하이머병, 주요 우울 장애 및 기타 질환의 치료에 널리 적용될 수 있음을 결론지었다.
2021년, 상하이 자오퉁 대학교, 중국 상하이

PBM치료와 글림프계: 뇌 림프 배수 시스템 증진을 위한 유망한 응용

PBM을 통해 두개골 내외 림프계 기능을 촉진하는 것은 뇌척수액 유출 이상과 관련된 뇌 질환 치료에 효과적인 전략이 될 수 있다.
2022년 중국 합비, 합비 공과대학 재료과학공학부

PBM치료 및 세포 치료가 신경 재생 및 떨림 억제를 통한 파킨슨 병 개선

메타분석 결과, 세포 치료와 PBM치료를 함께 병행했을 시 파킨슨 (PD)의 증상을 개선할 수 있다.
2022년, 이란 테헤란, 샤히드 베헤쉬티 의과대학교, 의료과학 연구센터 레이저 응용

파킨슨병 환자에서 PBM 치료 후의 미생물체 변화: 후향적 연구

파킨슨병은 치료 옵션이 제한된 진행성 신경 장애이며, 장내 미생물군은 잠재적 치료 대상으로 간주되었다. 이 연구는 PBM이 파킨슨병 증상을 완화시키는 효과를 보여준 이전 연구의 대변 샘플을 후향적으로 분석했다. 특히, 복부, 목, 머리, 코에 12주간 PBM 치료 후, 장 건강의 지표인 바실러스류 대 바크테로이데테스 비율(F:B)의 유익한 변화가 관찰되었다.
2022년, 호주 시드니 NSW 2060, 에드워드 스트리트 40번지, 호주 가톨릭 대학교 보건과학부

Photobiomodulation: 우울증 치료를 위한 신흥 치료법

이 리뷰는 주요 우울장애에 대한 광생물 자극(PBM)의 유익한 효과가 기존 치료나 보완 치료에 저항성을 보인 환자들에게서도 나타남을 보여주었다.
2023년 하버드 의과대학, 매사추세츠 종합병원, 신경정신의학 및 신경조절과

급성 외상성 뇌 손상에서의 PBM 치료: 체계적 문헌고찰 및 메타분석

메타분석 결과, 최적의 PBM 파장은 665nm과 810nm인 것으로 확인되었으며 부상 후 4시간 이내 치료를 시작하여 국소 치료일 경우 하루 최대 3회 치료하였을 때 PBM이 세포생존, 염증, 증식, 대사에 긍정적인 영향을 미친다는 것을 보여준다.
2023년 영국 버밍엄 대학교, 에지바스턴, 버밍엄, 염증 및 노화 연구소, 신경과학 및 안과학과

뇌 폐기물 제거 시스템과 수면: 뇌 질환 야간 치료를 위한 혁신적인 전략으로서의 PBM 치료

최근 연구 결과 수면이 중추신경계 독소 제거에 필수적인 뇌 폐기물 제거 시스템을 활성화한다고 밝혔다. 이 시스템과 관련된 뇌수막 림프관은 알츠하이머병 및 파킨슨병과 연결되어 있다. 연구자들은 깊은 수면 중 PBM치료를 통해 이 시스템을 자극하는 것이 CNS 보호를 강화하고 뇌 질환 발병을 지연시킬 수 있는 새로운 방법으로 보고 있다.
2023년 훔볼트 대학교 물리학 연구소, 베르린, 영국

신경퇴행성 질환에서 PBM의 유익한 역할

PBM은 알츠하이머병, 파킨슨병, 간질, 외상성 뇌 손상, 뇌졸중 등 다양한 질환에 적용되며, 신경 기능 개선과 기존 약물 대비 안전한 대안을 제공할 수 있는 잠재력에 대해 연구되고 있다.
2023년, 대만 타이베이 11529, 국립 성공 대학교 및 아카데미아 시니카, 대만 국제 융합 신경과학 대학원 프로그램

우울 장애에서 저수준 빛 치료에 대한 간략한 리뷰

PBM은 ATP 생성을 증가시켜 혈류 개선, 염증 감소, 치유 촉진 및 줄기세포 성장을 자극한다. 사전임상 연구에서 PBM이 중추신경계 질환에 대한 신경보호 효과를 보여, 알츠하이머 환자의 뇌 기능 개선, 파킨슨 환자의 운동 문제 해소 및 우울증 증상 완화에 도움이 될 수 있음을 시사한다.
2023년, 호주 뉴사우스웨일스 주 시드니, 시드니 대학교 의과학부

복부 또는 다리를 대상으로 한 원격 PBM이 파킨슨병 MPTP 손상에 대한 효과적인 신경보호를 제공

PBM은 MPTP에 의해 유발된 파킨슨병(PD)의 주요 신경 경로의 손상을 방지하며, 복부와 다리 모두 원격 치료에 효과적인 대상이다.
2023년, 호주 뉴사우스웨일스 주 시드니, 시드니 대학교 의과학부

만성 스트레스를 받은 쥐에서 Sirt1과 신경염증 조절을 통한 뇌-장 PBM으로 인지 변화를 회복하는 연구

만성 불규칙 경미 스트레스(CUMS) 프로토콜은 행동 변화를 크게 유발하고 해마의 Sirt1 수치를 증가시킨다. 이 프로토콜에 광생물조절 치료(PBM)를 결합하면 CUMS에 의해 유발된 인지 장애를 역전시킬 수 있다. 이러한 역전은 해마의 Sirt1 수치를 정상화하고, 해마 CA1 영역의 척추 밀도 손실을 방지하며, 장내 미생물총을 변화시키고, 신경염증을 감소시키며, 미세아교세포 형태를 조절한다.
2024년 바르셀로나 대학교 의학대학, 생의학과, 신경과학 연구소, 스페인