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Related Papers - Brain

Brain- Gut Photobiomodulation Restores Cognitive Function



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Gut Photobiomodulation Restores Cognitive Function in Chronically Stressed Mice by Regulating Sirt1 and Neuroinflammation
Simultaneous photobiomodulation (PBM) of the brain and gut restored learning and memory deficits in chronically stressed mice by activating Sirt1 and suppressing neuroinflammation.
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What Did They Discover?
In a chronic stress mouse model, combined brain–gut PBM significantly improved cognitive performance and normalized both neuroinflammatory and gut dysbiosis markers. The study highlighted that enhanced Sirt1 expression played a key role in mediating these restorative effects.
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How Does It Work?
PBM upregulated the Sirt1 pathway, which inhibited inflammatory signaling cascades such as NF-κB, reducing microglial overactivation and pro-inflammatory cytokine production. Concurrently, PBM improved gut microbiota balance and intestinal barrier integrity, thereby lowering peripheral inflammation and stabilizing the brain–gut axis.
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Why Does It Matter?
Chronic stress–induced cognitive decline arises from interconnected brain inflammation and gut imbalance. This study shows that noninvasive light stimulation targeting both the brain and gut can simultaneously restore neural and intestinal health, offering a new integrative approach to managing stress-related cognitive dysfunction.

Key Mechanisms

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Sirt1 activation ↑ → NF-κB signaling ↓ → microglial inflammation ↓
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Gut microbiota normalization → reduced peripheral inflammation
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Stabilized brain–gut axis → improved hippocampal cognition
Conclusion
Brain–gut PBM activates Sirt1, suppresses inflammation, and restores cognitive function, presenting a promising noninvasive therapeutic strategy.