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Related Papers - Brain

Brain- Hydrogen Gas: From Inflammation Treatment to Cancer Therapy



pbm-1

WB-PBM Therapy

therapy-2

Hyperbaric Oxygen Therapy

therapy-3

Hydrogen Therapy

From Inflammation Treatment to Cancer Therapy
Nanomaterial-based H₂ delivery systems can achieve targeted hydrogen therapy with enhanced efficacy for cancer and inflammatory diseases
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What Did They Discover?
H₂ can be delivered via nanocarriers or nanogenerators to achieve targeted accumulation at disease sites, significantly improving therapeutic effects compared to systemic H₂ administration
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How Does It Work?
Three key mechanisms: Antioxidant (scavenging •OH and ONOO⁻), Anti-inflammatory (down-regulating IL-1β, IL-6, TNF-α), Anti-neoplastic (activating apoptosis via AMPK pathway)
listicon
Why Does It Matter?
Overcomes limitations of conventional H₂ therapy (poor targeting, low utilization) and enables synergistic effects with photothermal therapy, chemotherapy, and radiotherapy

Key Mechanisms: How H₂ Works

Mechanism
Action
Pathways Involved
Antioxidant
Selectively scavenges •OH, ONOO⁻
Nrf2, ERK1/2, JNK, Ca²⁺ signaling
Anti-inflammatory
Down-regulates cytokines
NF-κB, HMGB-1, TLR4
Anti-neoplastic
Enhances cancer cell apoptosis
AMPK, caspase-3, AIF
Selectivity is key:
H₂ only reduces toxic ROS while preserving signaling ROS

Nanomaterial Strategies

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H₂ Carriers
  • Microbubbles, Mg@p-SiO₂, mesoporous silica
  • Enable controlled release via stimuli (pH, light, ultrasound)
    • listicon
    H₂ Generators
  • PdH₀.₂ nanocrystals, liposomal nanoreactors
  • Produce H₂ in situ at tumor sites via photocatalysis
    • listicon
    Advantages
  • Passive targeting via EPR effect
  • Active targeting through surface modification
  • Sustained H₂ release at therapeutic concentrations
    • Conclusion
    Combining H₂ therapy with nanomaterials represents a paradigm shift from systemic to precision gas therapy. This approach enables targeted delivery, controlled release, and synergistic effects with conventional treatments, opening new avenues for cancer therapy and inflammatory disease management.
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