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Reference

Autoimmune

Autoimmune

Relieves Inflammation in Arthritis

Photobiomodulation ameliorates inflammatory parameters in fibroblast-like synoviocytes and experimental animal models of rheumatoid arthritis
Conclusion
  • The study was conducted on fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) and on a collagen-induced arthritis (CIA) mouse model.
  • Photobiomodulation (PBM) was applied using an LED with a wavelength of 610 nm for 20 minutes, and its anti-inflammatory and therapeutic effects were evaluated in both cellular and animal models.
  • PBM inhibited TNF-α–induced proliferation, migration, and invasion of FLS, and in CIA mice it reduced arthritic symptoms, inflammatory responses, and cartilage damage; when combined with methotrexate (MTX), it produced greater effects (p < 0.05).