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Related Papers - Brain

Brain- Hydrogen: The Antioxidant That Saves Cells



Nature Medicine 2007 | Nippon Medical School
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Hydrogen: The Antioxidant That Saves Cells
Hydrogen (H₂) gas selectively eliminates the most toxic reactive oxygen species, reducing brain damage by up to 70%
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What Did They Discover?
Hydrogen selectively scavenges •OH (hydroxyl radicals), the most toxic ROS, while preserving other reactive oxygen species essential for cell signaling
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How Does It Work?
In a rat cerebral infarction model, 2-4% H₂ gas inhalation reduced brain damage by 66% during reperfusion (more effective than existing treatments)
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Why Does It Matter?
H₂ rapidly diffuses across membranes to reach mitochondria and nuclei, offering potential treatment for ischemia-reperfusion injuries like stroke and myocardial infarction

Key Data:
Brain Damage Reduction by H₂ Concentration

H₂ Concentration
Infarct Volume
Reduction
H₂ 0% (Control)
200 mm³
-
H₂ 1%
140 mm³
30% ↓
H₂ 2%
68 mm³
66% ↓ ✓
H₂ 4%
73 mm³
63% ↓
    Optimal concentration:
    2-4% hydrogen gas | 90-min ischemia + 30-min reperfusion model
Conclusion
Hydrogen freely penetrates cell membranes and selectively eliminates toxic radicals, making it an ideal antioxidant. It represents a novel therapeutic strategy for acute oxidative stress diseases including stroke and organ transplantation.
Ohsawa et al., Nature Medicine (2007) Cited 1,924+ times | Landmark paper in hydrogen medicine