Thesis
Chronic disease-related
Effects of Sub-Normal Deuterium Levels on Human Metabolic Syndrome and Other Blood Parameters: A Preliminary Study
This study supports the potential beneficial role of deuterium-depleted water (DDW) in glucose metabolism disorders.
March 2020, HYD LLC Cancer Research and Drug Development Company, Budapest 1118, Hungary
Estimation of Hepatic Glyceroneogenesis in Human Type 2 Diabetes
Glyceroneogenesis is a metabolic pathway crucial for triglyceride synthesis in the liver, where glycerol is synthesized from pyruvate or other metabolic intermediates.
March 2008, MetroHealth Center, Schwartz Center for Nutrition and Metabolism, Cleveland, Ohio 44109, USA
. Metabolic Correction of Experimental Alloxan Diabetes through Antioxidant Therapy
Antioxidants reduce oxidative damage induced by alloxan and effectively improve metabolic function.
May 2017, Kuban State Medical University, Krasnodar, Russia; Kuban State University, Krasnodar, Russia
Direct In Vivo Characterization of Delta-5 Desaturase Activity in Humans Using Deuterium Labeling, Depending on Insulin Effects
Insulin has been found to increase delta-5 desaturase activity, demonstrating its key regulatory role in fatty acid metabolism.
April 1989, Inserm Unit 58, Biochemistry A Laboratory, Montpellier, France
Utilization of Hyperbaric Oxygen Therapy as an Adjunct Treatment for Diabetic Foot Ulcers
HBOT increases blood oxygen levels, improves circulation, reduces inflammation, and promotes cell regeneration, significantly accelerating wound healing. This suggests that HBOT could be a useful adjunct therapy for managing diabetic foot ulcers.
September 2013, Department of Clinical Sciences, Lund University, Lund, Sweden
Hyperbaric Oxygen Therapy for Treating Diabetic Foot Ulcers: A Health Technology Assessment
HBOT accelerates ulcer healing, reduces infection rates, and improves quality of life. Additionally, a cost-effectiveness analysis suggests that HBOT is an economically viable option for treating diabetic foot ulcers.
May 2017, Ontario Health Quality, Ontario, Canada
Arterial Deficiency: Hyperbaric Oxygen Therapy for Specific Problem Wounds
HBOT increases oxygen concentration in the blood, improves circulation, reduces inflammation, and enhances tissue regeneration, leading to significant improvements in wound healing. HBOT may be a promising adjunct therapy for treating wounds caused by arterial insufficiency.
November 2020, Legacy Emanuel Medical Center, Hyperbaric Medicine/Wound Healing, Portland, Oregon, USA
Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, Enhances Growth Factors, and Promotes Diabetic Wound Healing
HBOT reduces oxidative stress and inflammation while increasing growth factors that promote wound healing. The therapy improves blood circulation and cell regeneration, accelerating wound healing and making HBOT a promising treatment for managing diabetic wounds.
April 2023, University of the Balearic Islands (IUNICS), Community Nutrition and Oxidative Stress Research Group, Spain; Balearic Islands Health Research Institute (IdISBa), Translational Research on Aging and Longevity (TRIAL) Group, Spain
Hyperbaric Oxygen Exposure Improves Blood Glucose Levels and Muscle Oxidative Capacity in Type 2 Diabetic Rats
HBOT significantly improves blood glucose levels and enhances muscle oxidative capacity, demonstrating potential as a promising treatment for Type 2 diabetes management.
February 2010, Graduate School of Human and Environmental Studies, Kyoto University, Neurochemistry Research Laboratory, Kyoto, Japan
Hyperbaric Oxygen Therapy: Why Pressure is Good for Diabetic Foot Ulcers
HBOT enhances blood circulation, reduces inflammation, and promotes tissue regeneration, significantly improving wound healing rates. These findings suggest that HBOT is an effective adjunct therapy for diabetic foot ulcer management.
March 2022, Hyperbaric Medicine Center, Rijswijk, Netherlands, and Anesthesiology Department, Amsterdam University Medical Center (AMC), Netherlands
Mild Hyperbaric Oxygen Therapy Improves the Oxidative Capacity of Spinal Motor Neurons Controlling the Gastrocnemius in Type 2 Diabetic Rats
mHBOT increases oxygen supply, reduces oxidative stress, and improves motor neuron oxidative capacity, leading to enhanced nerve function. This suggests that mHBOT may be a promising therapy for diabetic neuropathy.
September 2016, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
Changes in Vascular Function: Effects of Hyperbaric Oxygen Therapy in Type 2 Diabetes Patients
HBOT improves endothelial function, increases blood flow, and normalizes vascular reactivity, demonstrating potential as a treatment for vascular health improvement in Type 2 diabetes patients.
March 2016, Gülhane Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Health Sciences University, Ankara, Turkey
Effects of Hyperbaric Oxygen Therapy on Implant Osseointegration in an Experimental Diabetes Model
HBOT increases bone blood flow, reduces inflammation, and promotes bone regeneration, significantly enhancing implant osseointegration. This suggests that HBOT may improve dental implant success rates in diabetic patients.
July 2018, Gülhane Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Health Sciences University, Ankara, Turkey
Topical Hyperbaric Oxygen Therapy for Treating Diabetic Foot Ulcers
Local HBOT delivers oxygen directly to the ulcer site, improving circulation, reducing inflammation, and promoting tissue regeneration, leading to significant wound healing improvements. HBOT is a valuable adjunct therapy for diabetic foot ulcers.
August 2022, Jan Długosz University, Faculty of Health Sciences, Częstochowa, Poland
Effects of Hyperbaric Oxygen Exposure on Cataract Development in a Diabetic Mouse Model
HBOT delays cataract progression and maintains lens transparency, indicating that it may be a potential therapy for preventing and treating diabetic cataracts.
December 2011, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
Effects of Hyperbaric Oxygen Therapy on Soft Tissue Necrosis Caused by Centipede Bites in Diabetic Patients
HBOT increases oxygen supply to necrotic tissues, reduces inflammation, and promotes cell regeneration, significantly improving wound healing. HBOT may be a promising therapy for soft tissue necrosis in diabetic patients.
July 2022, Bozyaka Training and Research Hospital, Hyperbaric Oxygen Medicine and Plastic Reconstructive and Aesthetic Surgery Departments, Health Sciences University, Turkey
Systematic Review and Meta-Analysis of Hyperbaric Oxygen Therapy for Lower Limb Ulcers in Diabetes
Multiple clinical trials confirm that HBOT accelerates ulcer healing, reduces ulcer size, and lowers infection rates, proving to be an effective adjunct therapy for managing diabetic lower limb ulcers.
July 2019, Peripheral Vascular Disease Research Centre, James Cook University, Townsville, Queensland, Australia
Editorial Perspective: Adjunctive Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers
HBOT improves circulation, reduces inflammation, and enhances cell regeneration, accelerating wound healing rates in diabetic foot ulcers.
May 2015, Legacy Emanuel Hyperbaric Medicine Center, Portland, Oregon, USA
Effects of Hyperbaric Oxygen Therapy on Bone Regeneration in Type 1 Diabetic Rats
HBOT improves blood flow, increases oxygen supply, promotes bone regeneration, and reduces inflammation, making it a promising adjunct therapy for treating bone damage in Type 1 diabetic patients.
November 2018, Morgana Potrich University, Faculty of Dentistry, Mineiros, Goiás, Brazil
Overview of Systematic Reviews: Effects of Hyperbaric Oxygen Therapy on Chronic Diabetic Foot Ulcers
Multiple systematic reviews confirm that HBOT promotes ulcer healing, reduces ulcer size, and lowers infection rates, proving to be an effective adjunct therapy for diabetic foot ulcer management.
June 2021, Shanghai Medical and Health Science University, China; Dongfang Hospital, Beijing University of Chinese Medicine, China
Therapeutic Effects of Hyperbaric Oxygen Therapy on Wound Healing Impairment in Diabetic Rats
HBOT increases oxygen supply to wounds, reduces inflammation, and promotes cell regeneration and angiogenesis, significantly enhancing wound healing. HBOT may be a promising treatment for diabetic wound care.
October 2014, Erasmus MC University Medical Center, Department of Plastic and Reconstructive Surgery, Rotterdam, Netherlands
Hyperbaric Oxygen Therapy Improves Pancreatic β-Cell Function and Hepatic Gluconeogenesis in a STZ-Induced Type 2 Diabetes Mouse Model
HBOT restores pancreatic β-cell function, increases insulin secretion, and improves hepatic gluconeogenesis regulation, positively influencing blood glucose control. HBOT may be a promising therapy for Type 2 diabetes management.
March 2022, Heinrich Heine University Düsseldorf, Faculty of Medicine, University Hospital Düsseldorf, Endocrinology and Diabetes Department, Düsseldorf, Germany
Potential Ophthalmic Complications and Contraindications of Hyperbaric Oxygen Therapy
HBOT may increase intraocular pressure, worsen myopia, and contribute to cataract formation in some patients, particularly those with pre-existing ophthalmic conditions. Therefore, comprehensive eye examinations are recommended before HBOT treatment.
January 2023, Heinrich Heine University Düsseldorf, Faculty of Medicine, University Hospital Düsseldorf, Endocrinology and Diabetes Department, Düsseldorf, Germany
Hyperbaric Oxygen Rapidly Improves Tissue-Specific Insulin Sensitivity and Mitochondrial Function in Type 2 Diabetes: A Randomized Placebo-Controlled Crossover Trial
HBOT enhances insulin sensitivity and improves mitochondrial function, optimizing energy production. This suggests that HBOT may be an effective treatment for Type 2 diabetes.
March 2021, School of Optometry and Vision Science, University of New South Wales, Kensington, Australia
The Role of Hyperbaric Oxygen Therapy in Platelet Aggregation in Non-Insulin-Dependent Diabetes Mellitus (NIDDM)
HBOT improves blood flow, reduces inflammation, and accelerates wound healing, making it a promising adjunct therapy for treating non-healing wounds in NIDDM patients.
June 2021, Faculty of Biomedical Engineering, Universitas Airlangga, Surabaya, Indonesia
Atypical Wounds and Hyperbaric Oxygen Therapy
HBOT improves blood circulation, reduces inflammation, and accelerates the wound healing process, making it a promising adjunct therapy for treating atypical wounds.
July 2019, Carol Dean Benedict Mitnick 1, Kelly Johnson-Arbor
Continuous Oxygen Delivery Accelerates Diabetic Wound Healing by Promoting Epithelialization and Angiogenesis While Reducing Inflammation
Sustained oxygen delivery stimulates epithelialization and angiogenesis while reducing inflammation, significantly improving wound healing rates. This suggests that continuous oxygen therapy may be an effective approach for diabetic wound care.
August 2021, Washington University, Department of Mechanical Engineering & Materials Science, St. Louis, USA; Washington University, Department of Orthopedic Surgery, St. Louis, USA
Hyperbaric Oxygen, Not Hyperbaric Air, Increases Insulin Sensitivity in Men with Type 2 Diabetes
HBOT significantly improves insulin sensitivity, whereas hyperbaric air does not, indicating that HBOT may be an effective treatment for insulin resistance and Type 2 diabetes management.
December 2020, Hyperbaric Medicine Unit, Royal Adelaide Hospital, Adelaide, Australia
Systematic Review and Meta-Analysis of Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers in Controlled Clinical Trials
HBOT accelerates ulcer healing, reduces ulcer size, and lowers infection rates, confirming its efficacy as an adjunct therapy for managing diabetic foot ulcers.
January 2021, All India Institute of Medical Sciences, College of Nursing, Rishikesh, Uttarakhand, India
Effects of Hyperbaric Oxygen Therapy on Mandibular Defect Regeneration in Diabetic Rats: An Animal Study
HBOT increases blood flow to the mandibular defect site, enhances bone regeneration, and reduces inflammation, significantly improving bone healing in diabetic rats.
February 2023, Alexandria University, Faculty of Dentistry, Department of Oral Biology, Alexandria, Egypt
Hyperbaric Oxygen Therapy Enhances Diabetic Wound Healing by Stimulating Fibroblast Proliferation and Endothelial Cell Angiogenesis
HBOT stimulates fibroblast proliferation and promotes endothelial cell-driven angiogenesis, leading to faster wound healing in diabetic patients.
October 2020, Diabetes, Endocrinology, and Metabolism Research Institute, Coventry & Warwickshire NHS Trust, Coventry, UK
Systematic Review Evaluating the Effects of Hyperbaric Oxygen Therapy on Blood Glucose Levels in Diabetes Patients
HBOT may have a positive impact on blood glucose regulation, improving insulin sensitivity and reducing inflammation.
October 2021, Diabetes, Endocrinology, and Metabolism Research Institute, Coventry & Warwickshire NHS Trust, Coventry, UK
Dissolved Oxygen from a Microalgae-Gel Patch Promotes Chronic Diabetic Wound Healing
Oxygen released from a microalgae-gel patch increases oxygen supply to the wound site, stimulates cell regeneration, and enhances angiogenesis, significantly improving wound healing rates.
May 2020, Nanchang University, First Affiliated Hospital, Department of Burn Surgery, Nanchang, Jiangxi, China
Systematic Review and Meta-Analysis of Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers
HBOT has been shown to be an effective adjunct therapy for managing diabetic foot ulcers.
January 2022, Nanchang University, First Affiliated Hospital, Department of Burn Surgery, Nanchang, Jiangxi, China
Hyperbaric Oxygen Therapy - From Mechanisms to Cognitive Improvement
HBOT may help improve cognitive function in diabetic patients.
October 2021, Tel Aviv University, Faculty of Life Sciences, School of Neurobiology, Biochemistry, and Biophysics, Tel Aviv, Israel
Orocecal Transit, Bacterial Overgrowth, and Hydrogen Production in Diabetes
Diabetic patients often experience gastrointestinal dysmotility, affecting digestion and nutrient absorption. Research shows that diabetics have prolonged orocecal transit time, leading to bacterial overgrowth and increased hydrogen gas production, which may contribute to dyspeptic symptoms and other digestive issues.
November 1993, University of Mannheim, Department of Clinical Psychology, Third Medical Department of Munich Schwabing Hospital, Germany
Hydrogen Gas Production After a Single Dose of Acarbose in Japanese Type 2 Diabetes Patients is Associated with a Decrease in Peripheral Blood IL-1β mRNA
IL-1β mRNA levels were found to decrease, suggesting that acarbose may influence not only diabetes management but also inflammatory response regulation.
May 2016, Naka Kinen Clinic, Ibaraki, Japan & University of Yamanashi, Yamanashi, Japan
Long-term Administration of Two New Alpha-glucosidase Inhibitors in Insulin-dependent Diabetes Patients: Effects on Glycemic Control, Insulin Requirements, and Breath Hydrogen Excretion
Alpha-glucosidase inhibitors improve glycemic control, reduce insulin requirements, and increase hydrogen excretion in breath, suggesting that these drugs influence gut microbiota activity, potentially benefiting diabetes management.
February 1988, Evangelismos Hospital, Second Internal Medicine Department, Athens University, Greece
A Novel Hydrogen Sulfide-releasing Compound, S-Propargyl Cysteine, Prevents STZ-induced Diabetic Nephropathy
S-propargyl cysteine releases hydrogen sulfide, demonstrating anti-inflammatory, antioxidant, and cytoprotective effects that significantly reduce the development and progression of diabetic nephropathy. This compound could be a promising candidate for preventing and treating diabetic nephropathy.
May 2016, Department of Pharmacology, Fudan University School of Pharmacy, Shanghai, China
Hydrogen-rich Water Supplementation Improves Lipid and Glucose Metabolism in Patients with Type 2 Diabetes or Pre-diabetes
Regular consumption of hydrogen-rich water may improve blood glucose control and cholesterol levels in patients with type 2 diabetes or prediabetes.
March 2008, Kajiya Clinic, Kyoto, Japan
Recent Research on the Mechanisms of Hydrogen Sulfide in Wound Healing in Diabetes
This study highlights hydrogen sulfide as a promising factor in improving diabetic wound management and suggests future research should focus on developing new H₂S donors and delivery systems to optimize therapeutic effects.
January 2024, School of Dentistry, Chongqing Medical University, Chongqing, China
Molecular Hydrogen Therapy Improves Organ Damage from Sepsis
Hydrogen therapy effectively reduces organ damage caused by sepsis by suppressing inflammation and oxidative stress, particularly reducing inflammatory markers and oxidative stress levels in major organs like the liver, lungs, and kidneys.
June 2016, Department of Intensive Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
Hydrogen Sulfide Alleviates Diabetic Neuropathy Pain Through NO/cGMP/PKG Pathway and μ-opioid Receptor Activation
H₂S therapy significantly alleviates diabetic neuropathic pain in experimental models. This effect is mediated by the activation of the NO/cGMP/PKG signaling pathway and the involvement of the μ-opioid receptor. These findings suggest that hydrogen sulfide may be a promising therapeutic agent for diabetic pain management, requiring further investigation for clinical applications.
May 2023, Department of Medical Administration, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, China
Hydrogen Protects Against Oxidative Stress and Exhibits Neuroprotective Effects in Experimental Diabetic Peripheral Neuropathy in Mice
Hydrogen therapy significantly reduces oxidative stress markers in neural tissues, improves nerve function, and alleviates symptoms of diabetic neuropathy. The neuroprotective effects are attributed to hydrogen’s antioxidant properties, reducing oxidative damage to nerve cells. These findings suggest hydrogen’s potential as a therapeutic strategy for managing diabetic neuropathy, though further studies in humans are necessary.
April 2023, Department of Neurology, Sixth Medical Center of the PLA General Hospital, Beijing, China
. Real-world Effectiveness and Safety of Hydrogen Inhalation in Chinese Patients with Type 2 Diabetes: A Single-group, Retrospective Study
Significant improvements in blood glucose control were observed, including reductions in fasting blood glucose and HbA1c levels. Lipid profiles, oxidative stress, and inflammatory markers also showed improvement. The therapy was well-tolerated with minimal side effects. However, the absence of a control group and the retrospective nature of the study indicate a need for additional randomized controlled trials to confirm these findings and understand the underlying mechanisms.
July 2023, College of Traditional Chinese Medicine, Shandong University, Jinan, China & Department of Microsurgery, Qingdao University Affiliated Hospital, Qingdao, China
Applications of Methane and Hydrogen-based Breath Tests in Gestational Diabetes and Gut Microbiome Research
Findings indicate a higher prevalence of small intestinal bacterial overgrowth (SIBO) in GDM patients, suggesting a link between gut microbiome imbalances and gestational diabetes. The study explores SIBO’s impact on increased inflammation, reduced vitamin absorption, and maternal-fetal health outcomes, emphasizing the importance of gut microbiome management in GDM care.
June 2021, Department of Obstetrics and Gynecology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Hydrogen Sulfide Inhibits Ca2+-induced Mitochondrial Permeability Transition Pore Opening in Type 1 Diabetes
This study explores the role of hydrogen sulfide (H₂S) in inhibiting Ca2+-induced mitochondrial permeability transition pore (MPTP) opening in type 1 diabetes. H₂S prevents MPTP opening, protects mitochondrial function, reduces oxidative stress, and promotes cell survival under hypercalcemic conditions.
August 2019, Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky, USA
Effects of Hydrogen-rich Water Produced by Alternating-current Electrolysis on Antioxidant Activity, DNA Oxidative Damage, and Diabetes-related Markers
Hydrogen-rich water (HRW) significantly enhances antioxidant activity, reduces DNA oxidative damage, and improves diabetes-related markers such as fasting blood glucose, fructosamine, and 1,5-anhydro-D-glucitol levels.
July 2020, Graduate School of Engineering, Osaka Prefecture University, Osaka, Japan
Subcutaneous Hydrogen Gas Injection as a Novel Effective Therapy for Type 2 Diabetes
Research demonstrates that subcutaneous hydrogen gas injection significantly improves various metabolic parameters in a type 2 diabetic mouse model. Treated mice showed decreased serum glucose, insulin, LDL, and triglyceride levels, increased HDL cholesterol levels, improved glucose tolerance, and insulin sensitivity. Additionally, diabetic nephropathy markers such as urine output and renal fibrosis were reduced.
January 2018, Department of Anesthesiology & Critical Care, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Zhejiang, China
Symbiotic Algae-Bacteria Dressing to Accelerate Diabetic Wound Healing
This study explores the use of a hydrogel containing Chlorella and bacteria to generate hydrogen, promoting diabetic wound healing. The dressing continuously produces hydrogen for 60 hours, acting as a potent antioxidant that removes reactive oxygen species and reduces inflammation. This process enhances cell proliferation and migration, leading to a 50% improvement in wound healing within 3 days.
January 2022, School of Medicine & School of Life Sciences, Nanjing University, Key Laboratory of Pharmaceutical Biotechnology, Nanjing, China
Effects of Glucose Removal and Hydrogen Generation via Photocatalysis on Diabetic Wound Healing
This study investigates an innovative approach to diabetic wound healing using a visible-light-responsive photocatalyst. This method removes excess glucose at the wound site, reducing glycation and inflammation while simultaneously generating hydrogen to counter oxidative stress and inflammation. The combined effect significantly enhances cell proliferation and migration, improving overall wound healing outcomes.
September 2022, Department of Biomedical Engineering, Shenzhen University, Guangdong Key Laboratory of Biomedical Measurement & Ultrasound Imaging, Shenzhen, China
Exogenous Hydrogen Sulfide (H₂S) Plays a Crucial Role in Autophagy Regulation for Diabetes-related Diseases
This study highlights exogenous hydrogen sulfide’s crucial role in managing diabetes and its complications by regulating autophagy, a key cellular process for degrading and recycling damaged components. H₂S removes damaged proteins and organelles, reduces oxidative stress and inflammation, and maintains cellular function, protecting tissues affected by diabetes. These findings suggest that exogenous H₂S could be a promising therapeutic approach for diabetes.
June 2021, Henan University, School of Basic Medicine, Henan International Joint Research Laboratory of Nucleoprotein Regulation, Kaifeng, China
Regulation of Hydrogen Sulfide Synthesis Improves Cardiac Function and Endothelial-dependent Vascular Relaxation in Diabetes
This study shows that enhancing hydrogen sulfide (H₂S) synthesis improves cardiac function and vascular health in diabetic mice. Increased H₂S synthesis led to better diastolic function, reduced myocardial stiffness, and improved vascular relaxation, supporting blood flow and blood pressure regulation. These findings indicate that H₂S supplementation may be beneficial for diabetic cardiovascular complications.
May 2021, Department of Circulatory Physiology, Bogomoletz Institute of Physiology, National Academy of Sciences, Kyiv, Ukraine
Hydrogen Sulfide (H₂S) and its Role in Diabetes and its Complications: Latest Research, Challenges, and Future Directions
Hydrogen sulfide plays a multifaceted role in diabetes onset and progression, acting as a signaling molecule that regulates numerous physiological processes. H₂S imbalances are linked to β-cell dysfunction, reduced insulin secretion, and increased oxidative stress, contributing to diabetes-related complications. Future research should explore H₂S-based therapies as potential interventions for diabetes management.
January 2023, School of Basic Medicine, Jiangnan University, Wuxi, China & Department of Pathology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
The Role of Hydrogen Sulfide in the Mechanisms of Diabetes Development and Complications
Hydrogen sulfide (H₂S) actively influences oxidative stress regulation, inflammation control, insulin secretion, insulin sensitivity, vascular health, and adipose tissue function in diabetes. H₂S therapy is emerging as a potential treatment option for diabetes and its complications.
July 2012, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, USA
Combination Effect of Methacrylate Powder Dressing (Altrazil Powder) and PBMT on Severe Diabetic Foot Ulcer Healing in Diabetic Patients: A Case Report
The combination of Altrazil Powder and PBMT may be effective in treating severe DFUs and provide additional benefits for improved healing outcomes.
May 2023, University of Louisville, Price Institute of Surgical Research & Noveratek LLC, Louisville, Kentucky, USA
PBMT Modulates Three-Dimensional Parameters, microRNA-21, and FGF2 Expression to Improve Inflammatory Response
PBMT is a promising non-invasive treatment that enhances wound healing by improving inflammatory response, increasing microRNA-21 and FGF2 expression, and modulating inflammation-related mechanisms.
May 2023, University of Louisville, Price Institute of Surgical Research & Noveratek LLC, Louisville, Kentucky, USA
Antihyperalgesic Effects of 904nm PBMT Suggest Modulation of MAPK Pathway and Calcium Dynamics in Streptozotocin-induced Diabetic Neuropathy
904nm PBMT may reduce pain hypersensitivity associated with diabetic neuropathy.
October 2022, Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil
PBMT Promotes Angiogenesis in Diabetic Mice with Hindlimb Ischemia
PBMT has potential angiogenesis-promoting effects in diabetic mice suffering from hindlimb ischemia.
July 2021, China Medical University, Department of Physical Therapy & Graduate Institute of Rehabilitation Science
PBMT Improves Hyperglycemia and Insulin Resistance by Activating Cytochrome c Oxidase-mediated Protein Kinase B in Muscle
PBMT shows potential as a non-invasive treatment for effectively improving metabolic abnormalities associated with type 2 diabetes.
May 2021, Ministry of Education Key Laboratory of Laser Life Science & Laser Life Science Research Institute, South China Normal University, Guangzhou, China
PBMT Reduces Free Fatty Acid Generation and Release in Adipocytes to Improve Insulin Resistance in Type 2 Diabetes
PBMT demonstrates promising effects in improving insulin resistance by reducing free fatty acid (FFA) generation and release in adipocytes.
April 2019, Ministry of Education Key Laboratory of Laser Life Science & Laser Life Science Research Institute, South China Normal University, Guangzhou, China
Effect of PBMT on Insulin Secretion in Porcine Islets
PBMT, a non-invasive therapy using specific light wavelengths interacting with tissues, enhances insulin secretion.
May 2022, Department of Physics and Geosciences, Angelo State University, Texas Tech University System, San Angelo, Texas, USA
Impact of PBMT on Fibroblast Growth Factors and the Ras/MAPK Signaling Pathway
PBMT may be an effective adjunct therapy for diabetic wound healing through its effects on growth factors and signaling pathways.
October 2022, Laser Research Center, University of Johannesburg, South Africa
PBMT for Insulin Resistance Treatment
PBMT has been shown to enhance mitochondrial function, increase glucose uptake, and improve insulin signaling pathways.
August 2022, School of Physical Education, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Brazil
Physical Therapy for Diabetic Foot Ulcers: Research Progress and Clinical Application
PBMT accelerates wound healing and reduces inflammation by stimulating cellular processes using light therapy.
April 2023, School of Pharmacy, Bengbu Medical College, Anhui Province, China
Can PBMT Regulate Blood Glucose Levels and Alter Muscle Glycogen Synthesis?
PBMT has efficacy in regulating blood glucose levels and enhancing muscle glycogen synthesis.
April 2020, Graduate Program in Biomedical Engineering, University of São Paulo, São Paulo, Brazil
Photobiomodulation in the Treatment of Non-Central Diabetic Macular Edema Patients
PBMT was confirmed as a non-invasive and cost-effective treatment option for patients with non-central diabetic macular edema (NCDME).
October 2014, Department of Ophthalmology, University of Kansas Medical Center, Prairie Village, Kansas, USA
PBM Therapy Mitigates Diabetic Retinopathy Using Pigmented Mouse Model: Insights into Direct and Indirect Mechanisms
PBMT affects retinal tissue through direct interaction and systemic biological changes.
October 2015, Case Western Reserve University, Cleveland, Ohio, USA & Wayne State University, Detroit, Michigan, USA
Enhancing Metabolic Stability through Deuterium Usage: Discovery of HWL-066, a Potent and Durable Free Fatty Acid Receptor 1 Agonist
The metabolic stability improvement achieved through deuterium incorporation enhances the clinical applicability of this drug.
August 2018, China Pharmaceutical University, State Key Laboratory of Natural Medicines, Drug Discovery Center, Nanjing, China; Guangdong Pharmaceutical University, School of Pharmacy, Guangzhou, China; Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, China
Hyperbaric Oxygen Therapy and Diabetic Vascular Complications
HBOT improves blood circulation, reduces inflammation, and promotes wound healing, potentially slowing the progression of diabetic vascular complications.
November 2020, University of Belgrade, 'VINČA' Institute of Nuclear Sciences, Serbia; Faculty of Medicine, University of Belgrade, Endocrinology and Diabetes Department, Clinical Center of Serbia, Belgrade; Business Academy University of Novi Sad, Faculty of Dentistry, Pančevo, Serbia
PBMT Suppresses Long-term Structural and Functional Damage in Diabetic Retinopathy
PBMT effectively inhibits the progression of diabetic retinopathy.
November 2017, Case Western Reserve University, Cleveland, Ohio, USA & Second Hospital of Jilin University, Changchun, Jilin, China
