Thesis
Autoimmune-related
Randomized Controlled Clinical Trial of Hydrogen/Oxygen Inhalation for Non-Alcoholic Fatty Liver Disease (NAFLD)
Hydrogen/oxygen inhalation improved systemic inflammation and liver histology in mice, promoting autophagy inhibited by chlorquine. It also reduced lipid accumulation in AML-12 cells and enhanced palmitic acid-induced autophagy with 20% hydrogen. Adding 3-methyladenine partially reversed hydrogen’s lipid-lowering effects. Overall, hydrogen/oxygen inhalation alleviated moderate to severe NAFLD.
2022, Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Anti-Inflammatory and Anti-Cancer Effects of Hydrogen Through Reactive Oxygen Species (ROS)
Hydrogen gas (H₂) therapy corrects oxidative and antioxidant imbalances and inhibits inflammatory mediators.
2018, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Hydrogen Consumption Alleviates Alcohol Intake and Hangover Symptoms in Healthy Adults: A Randomized, Controlled, Crossover Study
Hydrogen reduces blood alcohol concentration and alleviates hangover symptoms.
2022, Second Affiliated Hospital of Shandong First Medical University & Department of Basic Medicine, Shandong First Medical University, Tai'an, China
Hydrogen Inhalation Improves Liver Inflammation and Regulates Gut Microbiota in a High-Fat Diet-Induced NAFLD Mouse Model
NAFLD model mice received daily 4% H₂ inhalation for 2 hours. H₂ reduced liver inflammation, improved glucose tolerance, and lowered liver enzyme levels and inflammatory markers. Transcriptomic analysis showed inhibition of the LPS/TLR4/NF-κB pathway and enhanced gut barrier integrity. H₂ also positively altered gut microbiota composition.
2023, Taishan Hydrogen Medicine Research Institute, Shandong First Medical University, Tai'an, China
Molecular Imaging Tracks the Protective Effects of Inhaled Hydrogen Therapy in an Acute Lung Injury (ALI) Mouse Model
Research detected and monitored the antioxidant and anti-apoptotic effects of H₂ therapy as early as 24 hours after hyperoxia exposure. Results suggest the potential of SPECT biomarkers for in vivo evaluation of key ALI pathways and therapy response monitoring.
2017, Department of Biomedical Engineering, Marquette University, Milwaukee, WI, USA
Rationale for Using Oxygen-Hydrogen Gas as a Novel, Sustainable Therapy for COVID-19 and Other Respiratory Diseases
HHO therapy is highly relevant given the rising incidence of infectious viruses. There is an urgent need for sustainable and effective treatment protocols that can alleviate severe respiratory symptoms without relying on pharmacological interventions.
2021, Faculty of Applied Sciences, University of the West of England, Bristol, UK
Hydrogen/Oxygen Therapy for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD): A Multicenter, Randomized, Double-Blind, Parallel-Group Controlled Trial
Hydrogen/oxygen therapy was superior to oxygen therapy in AECOPD patients, with an acceptable safety and tolerability profile.
2019, Guangzhou Medical University, National Guangzhou Medical University Hospital, Respiratory and Critical Care Medicine, Guangzhou, China ________________________________________
A Recent Multicenter Open-Label Clinical Trial Shows Hydrogen-Oxygen Mixed Gas Inhalation Improves COVID-19 Disease Severity and Dyspnea
H₂-O₂ inhalation reduces airway resistance compared to room air and may play a role in COVID-19 treatment.
2020, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Hydrogen Inhalation Improves Ventilator-Induced Lung Injury (VILI)
Inhaled hydrogen gas effectively reduced inflammation associated with VILI at both local and systemic levels through its antioxidant, anti-inflammatory, and anti-apoptotic effects.
2010, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Hydrogen Gas (XEN) Inhalation Improves Airway Inflammation in Patients with Asthma and COPD
A single 45-minute session of low-dose hydrogen (XEN) inhalation showed positive therapeutic effects on airway inflammation in patients with asthma and COPD.
2020, Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
Therapeutic Effects of Hydrogen on Chronic Graft-Versus-Host Disease (cGVHD)
Findings suggest that hydrogen has potential as an effective and safe treatment for cGVHD, providing new insights into cGVHD therapy with significant theoretical value.
2017, Department of Hematology, Navy General Hospital, Beijing, China
Molecular Hydrogen as an Inert Gas with Clinical Efficacy
Delivered through local, non-oral, or gastrointestinal routes, H₂ improved clinical endpoints and surrogate markers in various metabolic and chronic systemic inflammatory diseases. Recognized for its broad biological activity, H₂ is emerging as a key player in medical gas therapy.
2015, University of Novi Sad, Department of Sports Biomedicine, & University of Belgrade, Department of Biomedical Sciences, Serbia
Advances in Hydrogen Medicine: Potential for Preventive and Therapeutic Applications of Molecular Hydrogen
In addition to its effects on oxidative stress, H₂ exhibits anti-inflammatory and anti-allergic properties. However, the molecular mechanisms underlying its significant effects at extremely low concentrations remain elusive.
2011, Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Nihon Medical School, Japan
Hydrogen: A Potential Adjunctive Therapy for COVID-19 Patients
Hydrogen has demonstrated antioxidant, anti-inflammatory, hormonal regulatory, and anti-apoptotic properties. A review of studies suggests H₂ may mitigate the cytokine storm and lung injury induced by SARS-CoV-2 during the early stages of COVID-19, potentially reducing severe disease progression.
2020, Department of Critical Care Medicine, Sichuan Provincial People's Hospital, Chengdu, China
Overcoming Oxidative Stress and Inflammation in COVID-19 with Molecular Hydrogen Therapy: Mechanisms and Perspectives
H₂ inhibits NF-κB inflammatory signaling, activates the Nrf2/Keap1 antioxidant pathway, improves mitochondrial function, and enhances cellular energy. Various preclinical and clinical studies have confirmed the benefits of H₂ in diseases, including COVID-19.
2021, Department of Nutrition and Dietetics, Faculty of Health Sciences, Igdir University, Turkey
Beneficial Effects of Hydrogen Gas Inhalation in an Allergic Rhinitis Mouse Model
Inhaled hydrogen has been shown to prevent or reduce pathological and biochemical changes in conditions such as cerebral infarction, lung transplant injury, liver damage, intestinal ischemia, cisplatin-induced nephrotoxicity, skin anaphylaxis, systemic inflammation, and asthma.
2018, Department of Otolaryngology-Head and Neck Surgery, China
Chemical and Biochemical Aspects of Molecular Hydrogen: Approaches for Treating Kawasaki Disease and COVID-19
Kawasaki-like disease induced by COVID-19, commonly seen in children, is a multi-system inflammatory syndrome. Molecular hydrogen, a stable antioxidant, may be useful in treating such conditions.
2021, Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Taiwan
Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Mitochondrial Stress Suppression
This study proposes a possible mechanism by which hydrogen inhibits mitochondrial oxidation and NLRP3 inflammasome activation, suggesting that hydrogen therapy could be a solution for chronic inflammatory diseases, including COVID-19.
2021, MiZ Research Institute, Kanagawa, Japan & University of California, Berkeley, Department of Molecular & Cell Biology, USA
Effects of Molecular Hydrogen Therapy on Organ Damage Induced by Sepsis
Hydrogen therapy significantly alleviated inflammation and oxidative stress, reducing multi-organ damage caused by sepsis, making it a promising strategy for improving survival.
2016, Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
Low-Level Laser Therapy (Class I, II, and III) for the Treatment of Rheumatoid Arthritis
LLLT can be considered a treatment option for reducing pain and morning stiffness in patients with rheumatoid arthritis, especially as it has no side effects.
2005, School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, Canada
Low-Level Laser Therapy Improves Disease Progression in a Mouse Model of Multiple Sclerosis
The results suggest that LLLT can be therapeutically applied during the autoimmune neuroinflammatory response period in diseases such as MS.
2014, Institute of Autoimmunity and Immunopharmacology, Araranguá Campus, Federal University of Santa Catarina, Araranguá, SC, Brazil
Orthopedic Implant Hypersensitivity: Characterization of Clinical Manifestations and the Effect of Photobiomodulation Therapy
Among 14 patients diagnosed with orthopedic implant hypersensitivity (OIH), 12 showed localized eczema at the implant site, and 2 had systemic eczema. Seven patients (50%) showed improvement after PBMT and were able to discontinue systemic steroids.
2023, Institute of Dermatology, Hverian Magnetic Therapy Hospital, Butcherschi Medical Foundation, Hverian, Taiwan
Photobiomodulation Therapy for Xerostomia in Pediatric Patients with Systemic Sclerosis
PBM therapy was effective in managing xerostomia (dry mouth) in pediatric patients, increasing salivary flow and improving quality of life.
2020, Department of Pediatric Clinical Morphology, School of Dentistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil
PBM Modulates IL-10 and IFN-γ Production by Mononuclear Cells in Healthy Donors and Multiple Sclerosis Patients
PBM differentially affected cytokine production depending on the light dose and wavelength. In patients with severe disease, 670 nm light increased IL-10 production, suggesting PBM may regulate cytokine responses throughout the course of MS.
2022, Department of Biomedical Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA
Comparison of Abdominal and Transcutaneous Tail Vein PBM in an Experimental Mouse Model of Ulcerative Colitis
The results suggest that PBM is effective in treating ulcerative colitis (UC) in an experimental mouse model.
2023, Department of Medical Biophotonics, Nove de Julho University (UNINOVE), Vergueiro Street 239/245, São Paulo, SP, 01504-000, Brazil
Effects of PBM on the T3/T4 Ratio and Quality of Life in Hashimoto’s Thyroiditis
PBM significantly improved the T3/T4 ratio, reduced TPO antibody levels, and lowered daily LT4 replacement therapy doses. These effects were primarily due to PBM's anti-inflammatory properties, leading to significant symptom improvement in Hashimoto’s thyroiditis.
2020, General Surgery, Bağcılar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
Reduction in Nitrate Production in Peripheral Blood Mononuclear Cells Isolated from Multiple Sclerosis Patients by PBM at 830 nm
PBM at 830 nm (10 J/cm², 72 hours) significantly reduced nitrate levels regardless of disease severity, indicating that PBM can effectively mitigate oxidative stress in MS at different stages.
2022, Department of Biomedical Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA
Molecular and Cellular Mechanisms in Arthritis: A New Beginning for Applied PBM
PBM provides a cost-effective alternative to pharmacological treatments, offering rapid and positive therapeutic responses with no side effects.
2020, Department of Medical Physics, Alexandru Ioan Cuza University, Carol I Boulevard 11, 700506 Iași, Romania
PBM Therapy on Skeletal Muscle Exposed to Diabetes: A Systematic Review of Animal Studies
PBM therapy reduced inflammation and improved angiogenesis and muscle regeneration in diabetic rats, particularly in type 1 diabetic models. Additionally, PBMT regulated oxidative stress in type 1 diabetes and reduced muscle lipidosis in type 2 diabetes.
2023, Department of Physiotherapy, Center for Biological and Health Sciences, Western Paraná State University, Cascavel, Paraná, 85819-110, Brazil
Low-Level Laser Therapy at Different Stages of Rheumatoid Arthritis: A Histological Study
LLLT significantly improved inflammatory markers and tissue characteristics in both early and advanced stages of rheumatoid arthritis (RA), including mononuclear cell infiltration, hemorrhage, hyperemia, necrosis, fibrocartilage distribution, and chondrocyte/bone cell density (p<0.05).
2013, Nove de Julho University, São Paulo, Brazil
Improvement of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice Induced by 670 nm Light PBM
PBM at 670 nm reduced disease severity in treated mice compared to untreated mice. The improvements were associated with decreased pro-inflammatory cytokines (IFN-γ, TNF-α) and increased anti-inflammatory cytokines (IL-4, IL-10).
2012, School of Health Sciences, University of Wisconsin-Milwaukee, USA
Systemic Effects of Physical Exercise and Low-Level Laser Therapy on Ankle Joints in an Experimental Rheumatoid Arthritis Model
LLLT and exercise improved both functional and structural aspects of joint tissue in an experimentally induced rheumatoid arthritis rat model.
2022, Department of Biological and Health Sciences, Western Paraná State University, Cascavel, Paraná, Brazil
PBM Improves Inflammatory Parameters in Fibroblast-Like Synoviocytes and an Experimental Model of Rheumatoid Arthritis
PBM effectively reduced TNF-α activity and suppressed NF-κB and NLRP3 inflammasome activation in RA-FLSs, reducing cartilage degradation and joint inflammation. When combined with MTX, PBM exhibited even stronger anti-rheumatic effects.
2023, Biomedical Convergence Research Institute, Pusan National University Yangsan Hospital, South Korea
Therapeutic Effects of PBM for Multiple Sclerosis by Modulating Inflammatory Processes and Immune Cell Activity
PBM regulates inflammation, modulates immune cell function, and reduces free radical generation, alleviating neurological deficits and improving functional outcomes in MS patients.
2022, Department of Anatomy, Cellular & Molecular Research Center, Birjand University of Medical Sciences, Iran
Clinical Feasibility of PBM Combined with Supplements in Hashimoto’s Thyroiditis: A 6-Month Parallel Trial
This study demonstrated that combining PBM with supplements effectively restored thyroid function, anthropometric parameters, and lifestyle in Hashimoto’s thyroiditis patients.
2008, Faculty of Medicine, University of Pristina, Kosovo
Mechanisms and Efficacy of PBM Therapy in Arthritis: A Comprehensive Review
This review provides key insights into parameters, modeling techniques, and evaluation methods for future research on PBM in arthritis treatment.
2023, Shenzhen University, China
Role of Low-Level Laser Therapy in Multiple Sclerosis Treatment: A Comprehensive Review
LLLT reduced pro-inflammatory immune cells and mediators while promoting neuronal repair and regeneration in MS.
2021, Laser Applications Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Low-Level Laser Therapy for Rheumatoid Arthritis: A Review of Experimental Approaches
Through literature review, LLLT demonstrated potential to improve quality of life in rheumatoid arthritis patients by reducing pain and enhancing physical activity.
2022, Laser Applications Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Effects of PBM on Atrophic-Erosive Oral Lichen Planus: A Systematic Review
PBM effectively improved symptoms of atrophic-erosive oral lichen planus without side effects, offering a favorable alternative to corticosteroids.
2022, Department of Dentistry, University of Murcia, Spain
PBM for Gingival Lesions Due to Autoimmune Diseases: A Systematic Review and Meta-Analysis
PBM significantly reduced pain and clinical scores of autoimmune gingival lesions, showing no significant difference compared to topical corticosteroids.
2022, Department of Dentistry, Federal University of Alfenas, Brazil
Low-Level Laser Therapy for Autoimmune Thyroiditis Treatment
LLLT reduced thyroid inflammation and suppressed immune cell migration, promoting thyroid recovery.
2022, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Effects of Laser Phototherapy on Inflammatory, Musculoskeletal, and Autoimmune Diseases
LLLT is a non-invasive and cost-effective treatment that modulates immune responses and is effective for chronic inflammatory conditions.
2019, Duke University School of Medicine, Durham, NC, USA
Near-Infrared Light Protects Cardiomyocytes from Hypoxia and Reoxygenation Injury via Nitric Oxide-Dependent Mechanisms
Near-infrared (NIR) therapy exerts cardioprotective effects through nitric oxide (NO)-mediated mechanisms. During reoxygenation, NIR exposure reduced cell damage, lowered apoptosis markers, and increased NO levels. The study confirms that NIR enhances mitochondrial function and provides therapeutic benefits via NO signaling pathways.
2009, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
PBM Therapy as a Highly Promising Treatment for COVID-19
Given its efficacy in reducing acute pulmonary inflammation, PBM therapy is a promising treatment approach for managing acute respiratory distress syndrome (ARDS) in COVID-19 patients.
2021, Department of Orthodontics, Dental Implant Research Center, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
Mechanism of Hyperbaric Oxygen Therapy in Alleviating Autoimmune Encephalomyelitis: Reduction of IL-17a and GM-CSF Production by Autoreactive T Cells and Increased Immunosuppressive IL-10 in CNS Lesions
HBOT is being reviewed as a promising clinical therapy for multiple sclerosis (MS) by suppressing Th17 cells and increasing immunoregulatory CD4 T cells in central nervous system (CNS) lesions.
2021, Education and Research Center, Show Chwan Hospital, Kaohsiung Medical University, Taiwan
Molecular Hydrogen as a Novel Antioxidant and Anti-Inflammatory Treatment for Rheumatoid Arthritis (RA) and Related Diseases
Reactive oxygen species (ROS) play a key role in RA pathogenesis, influencing major inflammatory pathways. The most harmful ROS, hydroxyl radicals, are effectively neutralized by molecular hydrogen (H₂). Studies suggest that H₂, when combined with traditional RA treatments, can help reduce oxidative stress in patients. In early RA stages, hydrogen has shown remarkable therapeutic effects, aiding in diagnosis and management.
2013, Haradoi Hospital, Department of Rheumatology and Orthopedic Surgery, Japan
Potential Role of PBM Therapy in Disease Treatment and Prevention in the COVID-19 Era
PBM therapy is not only safe and effective in reducing inflammation, pain, and tissue healing but also influences gut microbiota. It is recommended for high-risk COVID-19 groups, such as the elderly and those with comorbidities, as it aids in recovery and mitigates the impact of reduced physical activity due to isolation.
2020, Faculty of Medicine and Health, University of Sydney, Sydney, Australia
