A Nitric Oxide(NO) Factory Inside Your Body – NitroBiome
Sustained-release NO metabolites for vascular, immune, brain, and gut health — all in one.
Nitric oxide fermented metabolite concentrate
Nitro Biome (Fermented Metabolites) vs. Typical Precursors
Not All Nitric Oxide Is Created Equal
Most nitric oxide supplements rely on precursors — such as nitrate and nitrite — which must be converted by enzymes or gut bacteria before they can take effect.
That means delayed action, inconsistent absorption, and reduced bioavailability.
That means delayed action, inconsistent absorption, and reduced bioavailability.
NitroBiome is fundamentally different
It delivers pre-activated nitric oxide metabolites — including nitrate, nitrite, and S-nitrosothiols — produced through advanced fermentation technology. This allows for immediate action, supporting healthy circulation, energy, and mental clarity — all without relying on your body’s enzymatic pathways.
- Rapid nitric oxide activation
- Naturally improved blood flow and vascular flexibility
- Enhanced absorption and higher effectiveness
What is Nitric Oxide (NO)?
Nitric oxide (NO) is a naturally occurring molecule in the human body that plays a crucial role in maintaining vascular health, brain function, immune balance, and energy metabolism. It functions as a signaling molecule, helping cells communicate with each other, and is especially known for its ability to dilate blood vessels, improving blood flow and reducing cardiovascular stress.
- Molecular Structure: Small, nonpolar gas molecule (O=N=O)
Main Functions:
- Vasodilation: NO produced by endothelial cells (eNOS) relaxes smooth muscle cells, lowering blood pressure.
- Immune Regulation: Macrophages (iNOS) release high concentrations of NO to destroy bacteria and viruses.
- Neurotransmission: NO, synthesized in neurons (nNOS), contributes to brain signaling, learning, and memory formation.
Background
In 1998, Dr. Louis J. Ignarro received the Nobel Prize in Physiology or Medicine for identifying nitric oxide (NO) as a naturally produced vasodilator in the human body. Later, along with Drs. Ferid Murad and Robert Furchgott, he demonstrated that NO plays roles in cell signaling, immune regulation, and neural communication throughout the body.
Up until now, supplements related to nitric oxide (NO) have been mainly based on precursor components that induce NO production in the human body. However, as the human body ages, the activity of the enzyme (NOS) that produces NO decreases, rapidly reducing the ability to produce nitric oxide.
To solve this problem of reduced NO production due to aging, ‘NitroBiome‘ was developed. NitroBiome directly supplies ‘NitroBiome’ nitric oxide metabolites obtained by specially fermenting natural vegetables rich in nitrate, thereby extending the half-life of NO in the human body and helping improve blood circulation, control blood pressure, and enhance immune function.
Up until now, supplements related to nitric oxide (NO) have been mainly based on precursor components that induce NO production in the human body. However, as the human body ages, the activity of the enzyme (NOS) that produces NO decreases, rapidly reducing the ability to produce nitric oxide.
To solve this problem of reduced NO production due to aging, ‘NitroBiome‘ was developed. NitroBiome directly supplies ‘NitroBiome’ nitric oxide metabolites obtained by specially fermenting natural vegetables rich in nitrate, thereby extending the half-life of NO in the human body and helping improve blood circulation, control blood pressure, and enhance immune function.
Phenolic Fermentation Products
A functional metabolite is obtained by fermenting plants or food materials containing natural phenol compounds, with various physiologically active functions. Through the fermentation process, the bioavailability of existing substances increases or new physiologically active substances are created.
Characteristics of phenolic fermentation products: Various functions such as antioxidant, antibacterial, anti-inflammatory, anticancer, blood sugar control, and immune enhancement.
Characteristics of phenolic fermentation products: Various functions such as antioxidant, antibacterial, anti-inflammatory, anticancer, blood sugar control, and immune enhancement.
Basic Understadning
Item
Precursor-based NO products
New NO product – NitroBiome
Physiological pathways and functions
Nitric oxide precursors
Fermented Metabolites
Definition
Raw material that induces NO production in the body
NO-related active substances are produced during the fermentation process of various vegetables such as cabbage and beet
Representative ingredients
L-Arginine, L-Citrulline, Nitrate (NO₃⁻), Nitrite (NO₂⁻)
NO derivatives, nitro compounds, phenolic fermentation products, functional metabolites
Physiological Benefits of
Nitric Oxide Metabolites in Human Body
Functional Areas
Mechanism of action
Expected effect
Circulatory health (blood circulation)
NO metabolites (nitrite, nitrate, RSNO, etc.) relax the vascular endothelium and induce vasodilation → increase in peripheral blood flow
- Blood pressure control
- Improvement of coldness
- Improvement of numbness in hands and feet, and peripheral blood flow disorder
- Reduction of cardiovascular burden
Vitality and energy metabolism
NO improves mitochondrial function, increases oxygen utilization efficiency, and supports oxidative phosphorylation pathways.
- Reduces fatigue
- Improves exercise performance
- Increases energy recovery
- Supports male vitality
Brain health (cognition/concentration)
NO helps transmit signals between nerve cells and increases cerebral blood flow through vasodilation.
- Improves concentration
- Improves memory
- Inhibits brain aging
- Suggests the possibility of preventing Alzheimer’s
Immunity regulation (inhibition of inflammation)
Some of the metabolites have antioxidant and anti-inflammatory effects and regulate macrophage (M1/M2) immune balance.
- Enhance immunity
- Suppress chronic inflammation
- Strengthen resistance to viruses and bacteria
Intestinal health (protection of microorganisms and mucous membranes)
Some NO metabolites contribute to the growth of beneficial intestinal bacteria (e.g., Lactobacillus) and improve intestinal mucosal blood flow.
- Balance of beneficial intestinal bacteria
- Helps regenerate the intestinal mucosa
- Improves digestive function
- Possible prevention of leaky gut syndrome
Who should choose NO?
- Hypertension/cardiovascular disease patients: blood pressure control and arterial stiffness relief
- Seniors (elderly): supplementation of decreased NOS enzyme activity
- Chronic Fatigue or Cognitive Decline: To improve cerebral blood flow
- Post-Workout Recovery: For a steady blood supply during repair
How to take & Precautions
- Dosage: 1 capsule once a day (with water right after a meal)
- Recommended Duration: At least 4 consecutive weeks for noticeable results
- Caution:
– People with allergies, pregnant or breastfeeding women, should consult a physician
– Overdose may cause stomach problems
– Check for drug interactions if you’re on medication
Precursor vs. Metabolite: What’s the difference?
Distinctive
Precursor-based products
Metabolite-based products (NitroBiome)
Definition
Precursors for NO production (L-Arg, NO3⁻, etc.)
NO activity-related substances produced by fermentation (NitroBiome, etc.)
Representative ingredients
L-Arginine, L-Citrulline, Nitrate (NO₃⁻), Nitrite (NO₂⁻)
Fermentation-derived metabolites using natural products such as vegetables, S-nitrosothiol and nitrophenols
Path of action
- eNOS pathway: L-Arg → NO
- Non-enzymatic pathway: NO₃⁻ → NO₂⁻ → NO (low-oxygen/acidic environment)
Fermentation products (e.g., RSNO, NO₂-phenol, etc.) directly induce NO reaction
Speed of action
Activation after digestion and liver metabolism → relatively slow
Some metabolites are rapidly absorbed from the intestine and induce NO activity.
Enzyme Need
eNOS, iNOS, etc., are required
Some act non-enzymatically, or are already produced during fermentation.
Sustainability
Short plasma half-life
Some ingredients can have a lasting effect on the intestinal mucosa.
Individual differences influence
Influenced by eNOS genotype, liver function, and gut microbiota status
The active ingredients are stabilized during the fermentation process, so there is little individual variation.
Compound effect
Mainly focused on vasodilation and improving blood flow
Including vasodilation and improved blood flow, antioxidant, anti-inflammatory, immune regulation, and intestinal microflora balance.
Genesis
Amino acids, mineral salts (NO3⁻, etc.)
Fermented vegetables, microbial metabolites
Absorption and action
Activation of the NOS pathway after hepatic absorption
Direct action after intestinal absorption
Range of effect
Focus on improving blood flow
Complex actions, including improving blood flow, systemic inflammation, intestinal environment, and immunity
Example Products
Citrulline, L-Arginine Supplements
NitroBiome, cabbage/fermented beet/pomegranate/kale/garlic/lettuce, etc.
Disclaimer: The above description is not intended to explain the efficacy, prevention, or treatment of the product, but rather a scientific and physiological explanation of nitric oxide metabolites. Therefore, for any illness, please consult your doctor.
Summary of Scientific Background
Related mechanisms
Explanation
RSNO (S-nitrosothiol)
Long-term stable release of NO and anti-inflammatory/antioxidant function
Nitrite (NO₂⁻)
Reduced to NO in acidic environments (stomach, tissues after exercise, etc.) and exhibits physiological activity
Nitrate (NO₃⁻)
Converted to nitrite by gut microbes and contributes to the gut-body-brain pathway
Why is “Metabolite-Based” better?
Enzyme-independent NO production mechanism
Even when endothelial NOS activity decreases due to diabetes, hypertension, or old age, NO production continues through the metabolite (nitrate → nitrite) pathway.
Long-term, stable NO release
NitroBiome’s nitric oxide metabolites are stored in the body in the form of S-nitrosothiol, and gradually release NO when needed. With just one intake, the vascular relaxation and immune enhancement effects last for more than 24 hours.
Gut-Brain-Vascular Axis Synergy
The intestinal microbiota activated during the fermentation process helps convert NO, thereby comprehensively supporting improved intestinal health, enhanced systemic circulation, and protection of cognitive function.
Product Specifications and Basic Features
Product Name
NitroBiome (Oral Nitric Oxide Supplement)
Main Ingredients
Fermented NO Metabolites (Nitrate, Nitrite, S-Nitrosothiol)
Main Benefits
Vasodilation, immune regulation, cognitive function support, gut microbiota balance
Dosage
Taken once a day with water or a beverage
Packaging
30 capsules (1-month supply)
Country of Manufacture / Importer
South Korea / HueLight Co., Ltd.
Clinical/research backup
Nobel Prize-winning research by Dr. Ignarro (1998)
2024 freelance platform “Elancer” collaboration simulation case study
Self-pilot clinical results (significant improvement in blood pressure and fatigue indicators)
Ready to Fuel Your Body with Revolutionary Cellular Energy?
Today, it is becoming clear that the root causes of many chronic diseases are closely related to gut microbes. “NitroBiome” is the only solution that balances NO function and the intestinal microbiome.
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Frequently Asked Questions
Is it effective for people with normal NOS enzymes?
Yes. Since both pathways (enzyme-dependent and independent) are activated, it supports general wellness and performance.
Can pregnant women take it?
Since safety data is limited, please consult a doctor before use.
How quickly can I feel the effects?
Although it varies from person to person, on average, people experience improvements in blood pressure, fatigue, and sleep after 2 to 4 weeks.
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