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Related Papers - Brain

Brain

Multiple H₂ Routes for Protection

Molecular Hydrogen as a Neuroprotective Agent
Conclusion
  • The study investigated the neuroprotective effects of hydrogen (H₂) therapy in animal models and human clinical studies experiencing neurodegenerative damage caused by oxidative stress.
  • Hydrogen was administered by three methods—H₂ gas inhalation, ingestion of H₂-dissolved water, and injection of H₂-dissolved saline—and acted primarily by selectively reducing highly toxic oxygen radicals (·OH) and peroxynitrite.
  • Hydrogen therapy significantly reduced oxidative stress and inflammation in brain ischemia–reperfusion injury (IRI) and other neurodegenerative diseases (p < 0.05), demonstrating neuroprotective effects and being proposed as a clinically safe and effective therapeutic alternative.