This study investigated the effects of brain–gut photobiomodulation (PBM) on restoring cognitive changes in mice subjected to chronic stress.
PBM treatment was administered for 6 minutes per day over 3 weeks, and it improved cognitive function by modulating Sirt1 levels and reducing neuroinflammation.
PBM was found to normalize Sirt1 levels in the hippocampus, regulate the composition of the gut microbiota, and reduce neuroinflammation, thereby ameliorating cognitive impairment induced by chronic stress (p < 0.05).