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Photobiomodulation Therapy and the Glymphatic System: Promising Applications for Augmenting the Brain Lymphatic Drainage System
Photobiomodulation (PBM) enhances the activity of the brain’s glymphatic and meningeal lymphatic systems, facilitating the clearance of neurotoxic waste such as amyloid-β.
What Did They Discover?
The study suggests that PBM strengthens glymphatic flow and meningeal lymphatic drainage, helping to reduce waste accumulation in the brain and improve the neuronal microenvironment.
How Does It Work?
PBM stimulates cytochrome-c oxidase within mitochondria, boosting cellular energy production and promoting nitric oxide (NO) release. This leads to vasodilation, enhanced cerebral blood flow, and improved cerebrospinal (CSF) and interstitial fluid (ISF) circulation, accelerating waste clearance.
Why Does It Matter?
Dysfunction of the glymphatic system is closely linked to neurodegenerative conditions such as Alzheimer’s disease. By activating this clearance pathway, PBM offers a novel, non-invasive approach to supporting brain health and preventing cognitive decline.
Key Mechanisms
Mitochondrial energy metabolism and blood flow enhancement
NO-mediated vasodilation
Stimulation of glymphatic inflow and outflow routes
Conclusion
PBM is emerging as an innovative, non-invasive technique that promotes lymphatic circulation in the brain and helps reduce the buildup of neurotoxic substances, contributing to improved neuronal health and cognitive function.
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